Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans.
about
Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joiningRecognition of vitamin B metabolites by mucosal-associated invariant T cellsHematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiencyMucosal-associated invariant T cell-rich congenic mouse strain allows functional evaluation.RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repairPAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line.A role for XLF in DNA repair and recombination in human somatic cells.Functional overlaps between XLF and the ATM-dependent DNA double strand break response.Strategies for B-cell receptor repertoire analysis in primary immunodeficiencies: from severe combined immunodeficiency to common variable immunodeficiency.Congenital defects in V(D)J recombination.Mutations in XRCC4 cause primordial dwarfism without causing immunodeficiency.MHC class I-related molecule, MR1, and mucosal-associated invariant T cells.XLF deficiency results in reduced N-nucleotide addition during V(D)J recombination.Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.A genome-wide association study for the incidence of persistent bovine viral diarrhea virus infection in cattle.When natural mutants do not fit our expectations: the intriguing case of patients with XRCC4 mutations revealed by whole-exome sequencing.Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes.Lymphopoiesis in transgenic mice over-expressing Artemis.Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog).Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination.Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70.Ontogeny of human mucosal-associated invariant T cells and related T cell subsets.PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice.Mutations in XLF/NHEJ1/Cernunnos gene results in downregulation of telomerase genes expression and telomere shortening.
P2860
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P2860
Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Cernunnos deficiency reduces t ...... repertoire in mice and humans.
@ast
Cernunnos deficiency reduces t ...... repertoire in mice and humans.
@en
type
label
Cernunnos deficiency reduces t ...... repertoire in mice and humans.
@ast
Cernunnos deficiency reduces t ...... repertoire in mice and humans.
@en
prefLabel
Cernunnos deficiency reduces t ...... repertoire in mice and humans.
@ast
Cernunnos deficiency reduces t ...... repertoire in mice and humans.
@en
P2093
P2860
P50
P356
P1476
Cernunnos deficiency reduces t ...... repertoire in mice and humans.
@en
P2093
Annick Lim
Benoit Florkin
Christelle Martin
Gabriella Vera
Jean-Pierre de Villartay
Paola Rivera-Munoz
Vincent Abramowski
P2860
P304
P356
10.1128/MCB.01057-12
P407
P577
2012-12-03T00:00:00Z