Structural mechanism of demethylation and inactivation of protein phosphatase 2A
about
Protein phosphatase 2A dysfunction in Alzheimer's diseaseThe metabolic advantage of tumor cellsAn integrated workflow for charting the human interaction proteome: insights into the PP2A systemPME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant gliomaPhosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's diseasePotential Role of Epigenetic Mechanism in Manganese Induced NeurotoxicityProtein Phosphatase 2A in the Regulatory Network Underlying Biotic Stress Resistance in PlantsPP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues.The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificityMechanisms of the scaffold subunit in facilitating protein phosphatase 2A methylationStructure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau DephosphorylationThe structural basis for tight control of PP2A methylation and function by LCMT-1.Crystal Structure of a Novel Esterase Rv0045c from Mycobacterium tuberculosisStructural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone.Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome DegradationAlpha4 is an essential regulator of PP2A phosphatase activityChemical Proteomic Profiling of Human MethyltransferasesRelevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data.Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A.Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease modelsCrystallization and preliminary X-ray analysis of a novel esterase Rv0045c from Mycobacterium tuberculosisDiscovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.The metabolic serine hydrolases and their functions in mammalian physiology and disease.Protein phosphatase 2A (PP2A) is increased in old murine B cells and mediates p38 MAPK/tristetraprolin dephosphorylation and E47 mRNA instability.Novel Vein Patterns in Arabidopsis Induced by Small Molecules.Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer.Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cellsA LCMT1-PME-1 methylation equilibrium controls mitotic spindle sizeDithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activitySingle-residue posttranslational modification sites at the N-terminus, C-terminus or in-between: To be or not to be exposed for enzyme accessFusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5.PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments.Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localizationCrystal structure of the human Tip41 orthologue, TIPRL, reveals a novel fold and a binding site for the PP2Ac C-terminus.Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse modelAssembly and structure of protein phosphatase 2A.Protein carboxyl methylation and the biochemistry of memory.Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target.
P2860
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P2860
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
@ast
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
@en
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
@nl
type
label
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
@ast
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
@en
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
@nl
prefLabel
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
@ast
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
@en
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
@nl
P2093
P3181
P1433
P1476
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
@en
P2093
Jeffry B Stock
Philip D Jeffrey
Yongna Xing
P304
P3181
P356
10.1016/J.CELL.2008.02.041
P407
P50
P577
2008-04-04T00:00:00Z