Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. - Wikidata - thesis-toulmin - TriplyDB

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.

http://www.wikidata.org/entity/Q33844595

about

The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes The pharmacological landscape and therapeutic potential of serine hydrolases Changes in Carboxy Methylation and Tyrosine Phosphorylation of Protein Phosphatase PP2A Are Associated with Epididymal Sperm Maturation and Motility Design of activated serine–containing catalytic triads with atomic-level accuracy Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer.Activity-based proteomic and metabolomic approaches for understanding metabolism Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay.Metabolic profiling reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity.A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors.How chemoproteomics can enable drug discovery and development Exploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platforms Target deconvolution techniques in modern phenotypic profiling.Translational synthetic chemistry.Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors.A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.The metabolic serine hydrolases and their functions in mammalian physiology and disease.Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival.Single-pot enzymatic synthesis of Dicer-substrate siRNAs Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms.Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition.Identification of selective covalent inhibitors of platelet activating factor acetylhydrolase 1B2 from the screening of an oxadiazolone-capped peptoid-azapeptoid hybrid library.Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2)Chemical approaches to study metabolic networks PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice.Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition.A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles.Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target.Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived β-lactone.Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis.Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6)Determining target engagement in living systems Activity-based probes for the study of proteases: recent advances and developments.Activity-based protein profiling: recent advances in probe development and applications.All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.

P2860

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P2860

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.

http://www.wikidata.org/entity/Q33844595

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年學術文章

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Academic cross-fertilization b ...... e methylesterase-1 inhibitors.

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Academic cross-fertilization b ...... e methylesterase-1 inhibitors.

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Academic cross-fertilization b ...... e methylesterase-1 inhibitors.

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Academic cross-fertilization b ...... e methylesterase-1 inhibitors.

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Academic cross-fertilization b ...... e methylesterase-1 inhibitors.

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PNAS.1015248108

P1433

Proceedings of the National Academy of Sciences of the United States of America

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Academic cross-fertilization b ...... e methylesterase-1 inhibitors.

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P2093

Anna E Speers

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Daniel A Bachovchin

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Daniel K Nomura

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Gregory C Fu

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Hugh Rosen

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Jacob M Berlin

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Justin T Mohr

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Peter Chase

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Peter S Hodder

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Stephan C Schürer

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P2860

A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A

PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma

The protein kinase complement of the human genome

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits

Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity

Structural mechanism of demethylation and inactivation of protein phosphatase 2A

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10.1073/PNAS.1015248108

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Benjamin Cravatt III

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