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Disruption of the integrin alphaLbeta2 transmembrane domain interface by beta2 Thr-686 mutation activates alphaLbeta2 and promotes micro-clustering of the alphaL subunitsThe structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signallingThe magic of bicelles lights up membrane protein structureAnnular anionic lipids stabilize the integrin αIIbβ3 transmembrane complex.NMR solution conformations and interactions of integrin alphaLbeta2 cytoplasmic tailsThe structure of an integrin/talin complex reveals the basis of inside-out signal transduction.Structure of an integrin IIb 3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activationInsight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid BilayerNMR analysis of the IIb 3 cytoplasmic interaction suggests a mechanism for integrin regulationBasic amino-acid side chains regulate transmembrane integrin signallingIntegrin α1 Has a Long Helix, Extending from the Transmembrane Region to the Cytoplasmic Tail in Detergent MicellesUnderstanding single-pass transmembrane receptor signaling from a structural viewpoint-what are we missing?Construction of covalent membrane protein complexes and high-throughput selection of membrane mimics.Structural basis of transmembrane domain interactions in integrin signaling.The final steps of integrin activation: the end gameTests of integrin transmembrane domain homo-oligomerization during integrin ligand binding and signalingDifferential repositioning of the second transmembrane helices from E. coli Tar and EnvZ upon moving the flanking aromatic residues.CW-EPR studies revealed different motional properties and oligomeric states of the integrin β1a transmembrane domain in detergent micelles or liposomesTransmembrane and Juxtamembrane Structure of αL Integrin in Bicelles.Multiscale simulations suggest a mechanism for integrin inside-out activation.Integrin αIIbβ3 transmembrane domain separation mediates bi-directional signaling across the plasma membrane.Inhibition of αIIbβ3 Ligand Binding by an αIIb Peptide that Clasps the Hybrid Domain to the βI Domain of β3.The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological LigandLocalized lipid packing of transmembrane domains impedes integrin clustering.Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activationIntegrin signalling at a glance.Regulation of integrin activity and signallingLinking integrin conformation to function.Multiple approaches converge on the structure of the integrin alphaIIb/beta3 transmembrane heterodimer.Kindling the flame of integrin activation and function with kindlinsImplications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function.A view into the blind spot: solution NMR provides new insights into signal transduction across the lipid bilayer.Integrin structure, activation, and interactionsIntegrin bi-directional signaling across the plasma membrane.Cholesterol as a co-solvent and a ligand for membrane proteins.β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins.A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors.The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3.Integrin αIIbβ3 inside-out activation: an in situ conformational analysis reveals a new mechanismTalin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structure of the Integrin IIb Transmembrane Segment
@ast
Structure of the Integrin IIb Transmembrane Segment
@en
Structure of the Integrin IIb Transmembrane Segment
@nl
type
label
Structure of the Integrin IIb Transmembrane Segment
@ast
Structure of the Integrin IIb Transmembrane Segment
@en
Structure of the Integrin IIb Transmembrane Segment
@nl
prefLabel
Structure of the Integrin IIb Transmembrane Segment
@ast
Structure of the Integrin IIb Transmembrane Segment
@en
Structure of the Integrin IIb Transmembrane Segment
@nl
P2093
P2860
P356
P1476
Structure of the Integrin IIb Transmembrane Segment
@en
P2093
Tobias S Ulmer
Tong-Lay Lau
P2860
P304
P356
10.1074/JBC.M801748200
P407
P577
2008-06-06T00:00:00Z