Structure and function of an RNase H domain at the heart of the spliceosome
about
Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centrePre-mRNA Splicing in Plants: In Vivo Functions of RNA-Binding Proteins Implicated in the Splicing ProcessStructural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2Mechanism for Aar2p function as a U5 snRNP assembly factorCrystal structure of Prp8 reveals active site cavity of the spliceosomeStructural basis for dual roles of Aar2p in U5 snRNP assemblyCrystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding proteinA conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligationStructural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active SiteInhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8Molecular architecture of the human U4/U6.U5 tri-snRNPThe DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly.Rapid screening of yeast mutants with reporters identifies new splicing phenotypes.CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome.The RNase H-like superfamily: new members, comparative structural analysis and evolutionary classification.Spliceosome Structure and FunctionPrp8, the pivotal protein of the spliceosomal catalytic center, evolved from a retroelement-encoded reverse transcriptaseThe reverse transcriptase-RNase H: from viruses to antiviral defense.Mechanisms and Regulation of Alternative Pre-mRNA SplicingRetroviral integrase superfamily: the structural perspective.Functional roles of protein splicing factors.Spliceosome activation: U4 is the path, stem I is the goal, and Prp8 is the keeper. Let's cheer for the ATPase Brr2!Conformational heterogeneity of the protein-free human spliceosomal U2-U6 snRNA complexATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8.The spliceosome as ribozyme hypothesis takes a second step.Model systems: how chemical biologists study RNA.Splicing of mRNA precursors: the role of RNAs and proteins in catalysis.Structural insights into RNA splicing.Nucleases: diversity of structure, function and mechanism.The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine.Structural analyses of the pre-mRNA splicing machineryStructural studies of the spliceosome: zooming into the heart of the machine.Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans.A snRNP's ordered path to maturity.Functional consequences of splicing of the antisense transcript COOLAIR on FLC transcription.Functions and regulation of the Brr2 RNA helicase during splicing.Real time monitoring of junction ribonuclease activity of RNase H using chimeric molecular beacons.Crystallization and biochemical characterization of the human spliceosomal Aar2-Prp8(RNaseH) complex.Emerging views about the molecular structure of the spliceosomal catalytic center.
P2860
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P2860
Structure and function of an RNase H domain at the heart of the spliceosome
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structure and function of an RNase H domain at the heart of the spliceosome
@ast
Structure and function of an RNase H domain at the heart of the spliceosome
@en
Structure and function of an RNase H domain at the heart of the spliceosome
@nl
type
label
Structure and function of an RNase H domain at the heart of the spliceosome
@ast
Structure and function of an RNase H domain at the heart of the spliceosome
@en
Structure and function of an RNase H domain at the heart of the spliceosome
@nl
prefLabel
Structure and function of an RNase H domain at the heart of the spliceosome
@ast
Structure and function of an RNase H domain at the heart of the spliceosome
@en
Structure and function of an RNase H domain at the heart of the spliceosome
@nl
P2093
P2860
P356
P1433
P1476
Structure and function of an RNase H domain at the heart of the spliceosome
@en
P2093
Alexey Rozov
Patrizia Fabrizio
Vladimir Pena
P2860
P304
P356
10.1038/EMBOJ.2008.209
P407
P577
2008-11-05T00:00:00Z