Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB
about
Complementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain InhibitorsIn Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruziThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsColloid formation by drugs in simulated intestinal fluid.Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol proteaseNovel cruzain inhibitors for the treatment of Chagas' disease.A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moietySynthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesainSmall molecule inhibitors of Smoothened ciliary localization and ciliogenesisMapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopyChemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.Drug discovery and human African trypanosomiasis: a disease less neglected?Detection and treatment of Trypanosoma cruzi: a patent review (2011-2015).Identification of novel benzimidazole derivatives as anti-Trypanosoma cruzi agents: solid-phase synthesis, structure-activity relationships and molecular docking studies.Development and validation of hydrophobic molecular fields derived from the quantum mechanical IEF/PCM-MST solvation models in 3D-QSAR.Optimization of peptidyl allyl sulfones as clan CA cysteine protease inhibitors.Phenotypic screening approaches for Chagas disease drug discovery.Discovery of a quinoline-based phenyl sulfone derivative as an antitrypanosomal agent.Identification of levothyroxine antichagasic activity through computer-aided drug repurposing
P2860
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P2860
Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Identification and Optimizatio ...... Cruzain, Rhodesain, and TbCatB
@ast
Identification and Optimizatio ...... Cruzain, Rhodesain, and TbCatB
@en
Identification and Optimizatio ...... Cruzain, Rhodesain, and TbCatB
@nl
type
label
Identification and Optimizatio ...... Cruzain, Rhodesain, and TbCatB
@ast
Identification and Optimizatio ...... Cruzain, Rhodesain, and TbCatB
@en
Identification and Optimizatio ...... Cruzain, Rhodesain, and TbCatB
@nl
prefLabel
Identification and Optimizatio ...... Cruzain, Rhodesain, and TbCatB
@ast
Identification and Optimizatio ...... Cruzain, Rhodesain, and TbCatB
@en
Identification and Optimizatio ...... Cruzain, Rhodesain, and TbCatB
@nl
P2093
P2860
P50
P356
P1476
Identification and Optimizatio ...... Cruzain, Rhodesain, and TbCatB
@en
P2093
Brian K Shoichet
Craig J Thomas
David J Maloney
James Inglese
Julia T Silveira
Kenny Kean-Hooi Ang
Michelle R Arkin
Patricia S Doyle
Rafaela S Ferreira
P2860
P356
10.1021/JM901069A
P407
P577
2010-01-14T00:00:00Z