The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism.
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Towards physiological complexity with in vitro single-molecule biophysicsThe Closing Mechanism of DNA Polymerase I at Atomic ResolutionMolecular dynamics study of the opening mechanism for DNA polymerase IMolecular events during translocation and proofreading extracted from 200 static structures of DNA polymerase.Structures of dNTP Intermediate States during DNA Polymerase Active Site AssemblyStructural evidence for the rare tautomer hypothesis of spontaneous mutagenesisDNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesionBidentate and tridentate metal-ion coordination states within ternary complexes of RB69 DNA polymeraseAmino Acid Templating Mechanisms in Selection of Nucleotides Opposite Abasic Sites by a Family A DNA PolymeraseStructural Factors That Determine Selectivity of a High Fidelity DNA Polymerase for Deoxy-, Dideoxy-, and RibonucleotidesKlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometryThe E295K Cancer Variant of Human Polymerase Favors the Mismatch Conformational Pathway during Nucleotide SelectionStructural Insights into DNA Replication without Hydrogen BondsSustained active site rigidity during synthesis by human DNA polymerase μMetal-Dependent Conformational Activation Explains Highly Promutagenic Replication across O6-Methylguanine by Human DNA Polymerase βCapture of a third Mg²⁺ is essential for catalyzing DNA synthesisDNA Polymerase Conformational Dynamics and the Role of Fidelity-Conferring Residues: Insights from Computational SimulationsInitiation of RNA synthesis by the hepatitis C virus RNA-dependent RNA polymerase is affected by the structure of the RNA template.DNA sequencing using polymerase substrate-binding kinetics.How a homolog of high-fidelity replicases conducts mutagenic DNA synthesisRB69 DNA polymerase structure, kinetics, and fidelity.Conformational dynamics of Thermus aquaticus DNA polymerase I during catalysis.Elucidation of kinetic mechanisms of human translesion DNA polymerase κ using tryptophan mutants.A conservative isoleucine to leucine mutation causes major rearrangements and cold sensitivity in KlenTaq1 DNA polymeraseHuman DNA polymerase θ grasps the primer terminus to mediate DNA repairHuman DNA Polymerase ν Catalyzes Correct and Incorrect DNA Synthesis with High Catalytic Efficiency.Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide additionSingle-molecule Förster resonance energy transfer reveals an innate fidelity checkpoint in DNA polymerase IThe expanded genetic alphabet.Conformational landscapes of DNA polymerase I and mutator derivatives establish fidelity checkpoints for nucleotide insertion.Prechemistry nucleotide selection checkpoints in the reaction pathway of DNA polymerase I and roles of glu710 and tyr766.Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity.Studying DNA-protein interactions with single-molecule Förster resonance energy transfer.Polymerase/DNA interactions and enzymatic activity: multi-parameter analysis with electro-switchable biosurfaces.Bunyaviridae RdRps: structure, motifs, and RNA synthesis machinery.Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases.dNTP-dependent conformational transitions in the fingers subdomain of Klentaq1 DNA polymerase: insights into the role of the "nucleotide-binding" state.Real-time single-molecule studies of the motions of DNA polymerase fingers illuminate DNA synthesis mechanismsProcessive Incorporation of Deoxynucleoside Triphosphate Analogs by Single-Molecule DNA Polymerase I (Klenow Fragment) Nanocircuits.Dynamics of the translocation step measured in individual DNA polymerase complexes.
P2860
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P2860
The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
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2011 թվականի մարտին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The Structure of a High Fideli ...... Nucleotide Selection Mechanism
@nl
The structure of a high fideli ...... ucleotide selection mechanism.
@ast
The structure of a high fideli ...... ucleotide selection mechanism.
@en
type
label
The Structure of a High Fideli ...... Nucleotide Selection Mechanism
@nl
The structure of a high fideli ...... ucleotide selection mechanism.
@ast
The structure of a high fideli ...... ucleotide selection mechanism.
@en
prefLabel
The Structure of a High Fideli ...... Nucleotide Selection Mechanism
@nl
The structure of a high fideli ...... ucleotide selection mechanism.
@ast
The structure of a high fideli ...... ucleotide selection mechanism.
@en
P2860
P3181
P356
P1476
The structure of a high fideli ...... ucleotide selection mechanism.
@en
P2093
Eugene Y Wu
Lorena S Beese
P2860
P304
19758-19767
P3181
P356
10.1074/JBC.M110.191130
P407
P577
2011-03-19T00:00:00Z