Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria - Wikidata - thesis-toulmin - TriplyDB

Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

http://www.wikidata.org/entity/Q27675792

about

New agents for the treatment of drug-resistant Mycobacterium tuberculosis Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase The physiological target for LeuRS translational quality control is norvaline The Role of a Novel Auxiliary Pocket in Bacterial Phenylalanyl-tRNA Synthetase Druggability Evaluation of the characteristics of leucyl-tRNA synthetase (LeuRS) inhibitor AN3365 in combination with different antibiotic classes A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue Genotyping Tools for Mycobacterium ulcerans-Drawbacks and Future Prospects Spectroscopic and mechanistic studies of heterodimetallic forms of metallo-β-lactamase NDM-1.Effect of an oxygenating agent on oral bacteria in vitro and on dental plaque composition in healthy young adults.Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.Discovery of bacterial fatty acid synthase type II inhibitors using a novel cellular bioluminescent reporter assay.Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase.Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent.Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis.Small-molecule arginase inhibitors.Discovery and preclinical development of new antibiotics.Antibacterial and osteo-stimulatory effects of a borate-based glass series doped with strontium ions.Developing Novel Antimicrobial and Antiviral Textile Products.Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.Long-term effects of single and combined introductions of antibiotics and bacteriophages on populations of Pseudomonas aeruginosa.Bifunctional antimicrobial conjugates and hybrid antimicrobials.A Polymorphism in leuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus aureus Antibacterial and Antibiofilm Effects of Boron on Different Bacteria.Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor.Potency and spectrum of activity of AN3365, a novel boron-containing protein synthesis inhibitor, tested against clinical isolates of Enterobacteriaceae and nonfermentative Gram-negative bacilli.Dimeric unnatural polyproline-rich peptides with enhanced antibacterial activity.A continuous assay for monitoring the synthetic and proofreading activities of multiple aminoacyl-tRNA synthetases for high-throughput drug discovery.The versatility of boron in biological target engagement.N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors.The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics.In Vitro and In Vivo Activity of DS86760016, a Novel Leucyl-tRNA Synthetase Inhibitor for Gram-Negative Pathogens.Evaluation of selected properties of a new root repair cement containing surface pre-reacted glass ionomer fillers.Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing Clinical and veterinary trypanocidal benzoxaboroles target CPSF3

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Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

http://www.wikidata.org/entity/Q27675792

description

2013 nî lūn-bûn

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2013 թուականի Մարտին հրատարակուած գիտական յօդուած

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2013 թվականի մարտին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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Discovery of a Novel Class of ...... against Gram-Negative Bacteria

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Discovery of a Novel Class of ...... against Gram-Negative Bacteria

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Discovery of a Novel Class of ...... against Gram-Negative Bacteria

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Discovery of a Novel Class of ...... against Gram-Negative Bacteria

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Discovery of a Novel Class of ...... against Gram-Negative Bacteria

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Discovery of a Novel Class of ...... against Gram-Negative Bacteria

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Discovery of a Novel Class of ...... against Gram-Negative Bacteria

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Discovery of a Novel Class of ...... against Gram-Negative Bacteria

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Discovery of a Novel Class of ...... against Gram-Negative Bacteria

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Antimicrobial Agents and Chemotherapy

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Discovery of a Novel Class of ...... against Gram-Negative Bacteria

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Anita Sheoran

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Ann O'Leary

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D Shekhar Reddy

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David M Livermore

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El Mehdi Keramane

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Fernando L Rock

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Holly Sexton

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Jacob J Plattner

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James A Nieman

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Kingsley Savariraj

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P2860

Norvaline is accumulated after a down-shift of oxygen in Escherichia coli W3110

The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex

Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans

A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylation

Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetase

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site

Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase

Overview of the CCP4 suite and current developments

Phasercrystallographic software

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1394-403

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3098292

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10.1128/AAC.02058-12

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3

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57

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Stephen Anthony Cusack

Andrés Palencia

Thibaut Crépin

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2013-03-01T00:00:00Z

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234084072

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23295920

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Gram-negative bacteria

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3591879

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