Structure and Allostery of the PKA RII Tetrameric Holoenzyme - Wikidata - thesis-toulmin - TriplyDB

Structure and Allostery of the PKA RII Tetrameric Holoenzyme

Structure and Allostery of the PKA RII Tetrameric Holoenzyme

http://www.wikidata.org/entity/Q27677190

about

Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder PKA: lessons learned after twenty years Assembly of allosteric macromolecular switches: lessons from PKA Localization and quaternary structure of the PKA RI holoenzyme Phosphoryl Transfer by Protein Kinase A Is Captured in a Crystal Lattice Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20 PKA RIα Homodimer Structure Reveals an Intermolecular Interface with Implications for Cooperative cAMP Binding and Carney Complex Disease Structures of inactive CRP species reveal the atomic details of the allosteric transition that discriminates cyclic nucleotide second messengers Disrupting the allosteric interaction between the Plasmodium falciparum cAMP-dependent kinase and its regulatory subunit Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme The roles of the RIIβ linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIβ protein kinase A: a small angle x-ray and neutron scattering study.A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes.PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum.Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIα activation in response to cAMP binding Tracking cancer drugs in living cells by thermal profiling of the proteome.Dynamic architecture of a protein kinase.Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology Structural insights into mis-regulation of protein kinase A in human tumors.Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT.An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes Hypothalamic PKA regulates leptin sensitivity and adiposity.AKAP12 mediates PKA-induced phosphorylation of ATR to enhance nucleotide excision repair Evolution of the eukaryotic protein kinases as dynamic molecular switches.Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome.Conformational equilibrium of N-myristoylated cAMP-dependent protein kinase A by molecular dynamics simulations.p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.Reciprocal regulation of PKA and Rac signaling.The switch helix: a putative combinatorial relay for interprotomer communication in cGMP-dependent protein kinase.Requirement for protein kinase A in the phosphorylation of the TGFβ receptor-interacting protein km23-1 as a component of TGFβ downstream effects.Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.Local cAMP signaling in disease at a glance Role of conformational entropy in the activity and regulation of the catalytic subunit of protein kinase A.Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics.Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain.β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ.Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit.Impact of kinase activating and inactivating patient mutations on binary PKA interactions.

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P2860

Structure and Allostery of the PKA RII Tetrameric Holoenzyme

http://www.wikidata.org/entity/Q27677190

description

2012 nî lūn-bûn

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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի փետրվարին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

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2012年論文

@zh-tw

2012年论文

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name

Structure and Allostery of the PKA RII Tetrameric Holoenzyme

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Structure and Allostery of the PKA RII Tetrameric Holoenzyme

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Structure and Allostery of the PKA RII Tetrameric Holoenzyme

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type

label

Structure and Allostery of the PKA RII Tetrameric Holoenzyme

@ast

Structure and Allostery of the PKA RII Tetrameric Holoenzyme

@en

Structure and Allostery of the PKA RII Tetrameric Holoenzyme

@nl

prefLabel

Structure and Allostery of the PKA RII Tetrameric Holoenzyme

@ast

Structure and Allostery of the PKA RII Tetrameric Holoenzyme

@en

Structure and Allostery of the PKA RII Tetrameric Holoenzyme

@nl

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SCIENCE.1213979

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Structure and allostery of the PKA RIIβ tetrameric holoenzyme

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Eric V Smith-Nguyen

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Malik M Keshwani

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Michael S Deal

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Ping Zhang

http://www.w3.org/2001/XMLSchema#string

Susan S Taylor

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P2860

The protein kinase complement of the human genome

Determination of domain structure of proteins from X-ray solution scattering

A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes

Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase

PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation

PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

Contribution of Non-catalytic Core Residues to Activity and Regulation in Protein Kinase A

Novel Isoform-Specific Interfaces Revealed by PKA RIIβ Holoenzyme Structures

Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

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712-716

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scholarly article

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3299394

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10.1126/SCIENCE.1213979

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6069

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335

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Alexandr P Kornev

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2012-02-01T00:00:00Z

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221822307

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22323819

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Protein kinase, cAMP dependent, catalytic, alpha

Protein kinase, cAMP dependent regulatory, type II beta

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3985767

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