Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation
about
The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cellsSOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradationSubstrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptorSrc kinase activation by direct interaction with the integrin beta cytoplasmic domainSubdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylationIdentification of substrates of human protein-tyrosine phosphatase PTPN22Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecturep140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activityNuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factorsStructural basis for the recognition of c-Src by its inactivator CskThe tyrosine kinase Csk dimerizes through Its SH3 domainPositive and negative regulation of T-cell activation through kinases and phosphatasesStructural basis for the autoinhibition of focal adhesion kinaseActivation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domainThe Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer CellsEffects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activityCrystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemiaStructure of the carboxyl-terminal Src kinase, CskStructure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitorCrystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitorsCrystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKsc-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutationsCrystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound stateStructural Basis for Selective Small Molecule Kinase Inhibition of Activated c-MetConformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036Structure of WbdD: a bifunctional kinase and methyltransferase that regulates the chain length of the O antigen inEscherichia coliO9aStructural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase DomainA genetically encoded 19F NMR probe for tyrosine phosphorylationbeta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosisReplacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responsesNegative regulation of Lck by Cbl ubiquitin ligaseCharacterization of Lnk. An adaptor protein expressed in lymphocytesMolecular dynamics and protein function.IRAK-4 inhibitors for inflammationLck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid raftsConformational changes in protein loops and helices induced by post-translational phosphorylation.A Src-like inactive conformation in the abl tyrosine kinase domainMutations in the catalytic loop HRD motif alter the activity and function of Drosophila Src64The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosisPhosphorylation site dynamics of early T-cell receptor signaling
P2860
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P2860
Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation
description
1996 nî lūn-bûn
@nan
1996 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
name
Structural basis for activatio ...... upon tyrosine phosphorylation
@ast
Structural basis for activatio ...... upon tyrosine phosphorylation
@en
Structural basis for activatio ...... upon tyrosine phosphorylation
@nl
type
label
Structural basis for activatio ...... upon tyrosine phosphorylation
@ast
Structural basis for activatio ...... upon tyrosine phosphorylation
@en
Structural basis for activatio ...... upon tyrosine phosphorylation
@nl
prefLabel
Structural basis for activatio ...... upon tyrosine phosphorylation
@ast
Structural basis for activatio ...... upon tyrosine phosphorylation
@en
Structural basis for activatio ...... upon tyrosine phosphorylation
@nl
P3181
P356
P1433
P1476
Structural basis for activatio ...... upon tyrosine phosphorylation
@en
P2093
H Yamaguchi
W A Hendrickson
P2888
P3181
P356
10.1038/384484A0
P407
P577
1996-12-05T00:00:00Z
P6179
1028166701