A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)
about
Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substratesGeneration of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavageInternally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8Interleukin-1β has trophic effects in microglia and its release is mediated by P2X7R pore.Crystal structure of an invertebrate caspaseAn Allosteric Circuit in Caspase-1Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tractA combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosisAn inquiry into protein structure and genetic disease: introducing undergraduates to bioinformatics in a large introductory courseDiscovery of an allosteric site in the caspasesSynthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin.Neuroprotection by the inhibition of apoptosis.Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions.Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate librariesAminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.Determinants of Macromolecular Specificity from Proteomics-Derived Peptide Substrate Data.Post-translational GPI lipid anchor modification of proteins in kingdoms of life: analysis of protein sequence data from complete genomes.Definition and redesign of the extended substrate specificity of granzyme B.The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.Combinatorial strategies for targeting protein families: application to the proteases.Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO.Using specificity to strategically target proteases.Positional scanning synthetic combinatorial libraries for substrate profiling.Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches.Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates.Neuroprotection by caspase inhibitors.Apoptosis and its clinical impact.Emerging principles in protease-based drug discovery.Growth Inhibition and Apoptosis with H31 Metabolites from Marine Bacillus SW31 in Head and Neck Cancer Cells.Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling.Solid-phase synthesis of C-terminal modified peptides.Analyzing protease specificity and detecting in vivo proteolytic events using tandem mass spectrometry.Small Molecule Active Site Directed Tools for Studying Human CaspasesThe protein structures that shape caspase activity, specificity, activation and inhibition.Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative ProteomicsProfiling protease activities by dynamic proteomics workflows.Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3.Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles.
P2860
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P2860
A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)
description
1997 nî lūn-bûn
@nan
1997 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
A combinatorial approach for d ...... -1beta converting enzyme (ICE)
@ast
A combinatorial approach for d ...... -1beta converting enzyme (ICE)
@en
A combinatorial approach for d ...... -1beta converting enzyme (ICE)
@nl
type
label
A combinatorial approach for d ...... -1beta converting enzyme (ICE)
@ast
A combinatorial approach for d ...... -1beta converting enzyme (ICE)
@en
A combinatorial approach for d ...... -1beta converting enzyme (ICE)
@nl
prefLabel
A combinatorial approach for d ...... -1beta converting enzyme (ICE)
@ast
A combinatorial approach for d ...... -1beta converting enzyme (ICE)
@en
A combinatorial approach for d ...... -1beta converting enzyme (ICE)
@nl
P2093
P3181
P1476
A combinatorial approach for d ...... -1beta converting enzyme (ICE)
@en
P2093
D W Nicholson
E P Peterson
J W Becker
K T Chapman
N A Thornberry
P304
P3181
P356
10.1016/S1074-5521(97)90258-1
P577
1997-02-01T00:00:00Z