Definition and redesign of the extended substrate specificity of granzyme B. - Wikidata - thesis-toulmin - TriplyDB

Definition and redesign of the extended substrate specificity of granzyme B.

Definition and redesign of the extended substrate specificity of granzyme B.

http://www.wikidata.org/entity/Q32003176

about

Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue Granzyme B cleavage of autoantigens in autoimmunity The major human and mouse granzymes are structurally and functionally divergent GraBCas: a bioinformatics tool for score-based prediction of Caspase- and Granzyme B-cleavage sites in protein sequences.Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1 Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level.Reaction kinetics of protease with substrate phage. Kinetic model developed using stromelysin.Definition of the extended substrate specificity determinants for beta-tryptases I and II.Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries Engineering exosite peptides for complete inhibition of factor VIIa using a protease switch with substrate phage.Substrate specificity of human kallikrein 2 (hK2) as determined by phage display technology.Phage display substrate: a blind method for determining protease specificity.Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics.Mapping protease substrates by using a biotinylated phage substrate library.Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.Engineering next generation proteases.Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2' of substrates.Proteomic profiling of proteases: tools for granzyme degradomics.Activation of apoptosis and its inhibition.Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.Profiling protein function with small molecule microarrays.The extended cleavage specificity of human thrombin.Global identification of peptidase specificity by multiplex substrate profiling.A triple-mutated allele of granzyme B incapable of inducing apoptosis.Altered autoantigen structure in Sjögren's syndrome: implications for the pathogenesis of autoimmune tissue damage.Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution.Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution.Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis.Apoptosis in normal and diseased oral tissues.IFN-γ-independent intraocular tumor rejection is mediated by a macrophage-dependent process that leaves the eye intact.Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity.

P2860

Q22254229-A196C311-2768-4D03-B00E-694AF5684DB8 Q24292195-35A1B4AE-219A-408C-BF0F-4E9C1B50B973 Q24614528-0F36D5D9-360C-40E7-BF29-89E6BD26CEBC Q24633095-FA198873-4892-4E76-A74D-F28537C6A114 Q24682724-C467936A-7E7E-4F66-B256-BFD67A57AF27 Q24812816-1E4C0E2D-1ED1-4790-909B-BD8A6DCB82A7 Q27629942-D20BAEE0-FFB0-43A6-9C41-09215444D5FB Q28288671-D3C9EC97-0638-45D4-873E-96314E4C0F91 Q28576643-05291192-B974-4B0B-B1F1-A11DD14F8008 Q28730835-8F0BC7C6-3033-4EE1-8A7B-79BC19BB2D06 Q30491097-DB2CCEE1-C665-4F1B-9E83-4E78A21A7902 Q30648176-054664DA-7DB7-4CA2-BB0B-83861C438438 Q30686434-D39A10CC-261D-4827-AD65-4D217F7E2F32 Q30882677-D7FFDC29-07A9-4F35-A11D-DBE25E31B1CB Q30905453-3CDA3426-DB33-434A-A758-1E9CAD548A60 Q31068008-1315E6C5-D01F-42C6-9668-23DFFFD5E0D9 Q31118897-9AF885B7-4A1F-4EE7-B726-D3D1EA376BDA Q33216390-14DC84D6-6FFA-4D17-A713-52075841AC3D Q33231728-3C25917E-CBA5-4F8F-9465-547F521A21D4 Q33240565-BD7F21FD-FAC1-4B4F-9573-B66B00C74ABA Q33247896-EFD9DD6F-7603-4D82-B64B-0413416D2C95 Q33428555-33D916B1-2DFF-4A68-ACB0-A89EC7FD48BD Q33497078-862EDA80-E42D-40A7-BAD5-C54D73C0D16D Q33566176-6A9619C9-44AB-4FE8-AF58-D84073A3BD5A Q33600040-FB8688AD-1291-4749-998B-44110DDE4ADC Q33833384-532019E4-1CA0-4451-A04B-C7E93CF075D4 Q33897989-7A094668-58CE-4867-B9BC-30024ABD2CAE Q33952825-1AD2263E-77C3-4607-8DA4-76463E152EB7 Q34037176-4787EA05-4553-4E75-BCFB-52980F7D9C24 Q34181932-892DB66E-0E4D-4149-ADBC-BB70F21DDDBB Q34424750-2A765FE4-51F5-4A32-9609-029FA6C43D8C Q34807231-C04B6823-E4B2-4289-B19B-871EC3AE05A9 Q35798719-6CF24DBD-018F-483F-81F6-07B1AD64C54C Q35841842-3D37A591-995B-4473-A60D-C442A66E8437 Q36010856-FD3C9E2E-4525-46D6-B2FB-FC93829D78BD Q36106303-F19E1A95-5AE9-49E6-ACF8-D04FE660576D Q36239688-407EEF22-3896-48BE-813D-D892AFDCBE8C Q36332704-508839F2-14F6-481E-BC33-3B766CE36905 Q36368546-B77EF063-AAEF-4ADF-92D0-15039A3D5057 Q36375304-FACF99C3-A797-496E-8BE6-66A34C426BF8

P2860

Definition and redesign of the extended substrate specificity of granzyme B.

http://www.wikidata.org/entity/Q32003176

description

1998 nî lūn-bûn

@nan

1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

1998年の論文

@ja

1998年論文

@yue

1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

name

Definition and redesign of the extended substrate specificity of granzyme B.

@ast

Definition and redesign of the extended substrate specificity of granzyme B.

@en

type

label

Definition and redesign of the extended substrate specificity of granzyme B.

@ast

Definition and redesign of the extended substrate specificity of granzyme B.

@en

prefLabel

Definition and redesign of the extended substrate specificity of granzyme B.

@ast

Definition and redesign of the extended substrate specificity of granzyme B.

@en

P1433

Q32003176-46B822FB-C697-4415-9E9A-B990F87E7A4A

P1476

Q32003176-8802F5B5-DCCA-4546-903C-E92CF0E02DA0

P2093

Q32003176-1B8AB9C8-88C0-426B-87BC-8CA3984222A6

Q32003176-7FD27DC3-2A95-46EA-9913-CEAA3D3659ED

Q32003176-D864605A-6875-43A3-94CD-9700DDC2386B

Q32003176-E8890780-76D3-4773-8AF6-2BB0134CEE21

P2860

Q32003176-0BD51864-8980-4A56-B2B5-1327938975CA

Q32003176-0E4FF1CF-B063-4112-A674-9A20961C6091

Q32003176-0EE868AB-0EDD-4C70-A0F5-5F6477CB2584

Q32003176-1A7C51C3-BFFA-439F-B0D3-75A8ABDA4D59

Q32003176-20FB755A-EC92-42B5-818B-7E38818C2F11

Q32003176-2B3F32B1-6746-4190-88FD-0BB7C740B3E4

Q32003176-316DC7C6-DA10-403E-B0E3-81607EA13803

Q32003176-33574E5F-4D1A-49A9-951D-9DF38DB58FA5

Q32003176-439F7670-177B-4A7D-8C96-CF50B64D9F76

Q32003176-4B6E1C9F-9845-4740-838D-BFEF8320162E

P304

Q32003176-B20EF34F-C228-484C-8A06-814003D19133

P31

Q32003176-27A5A634-79AA-46FF-9E1D-5B8F538AFA9F

P356

Q32003176-EA1B65F0-67F5-4474-A7D8-12FC21AE673D

P407

Q32003176-79107C25-3EC2-4351-A729-9A715E5EAE87

P433

Q32003176-EFD20397-CAC4-4AF5-9138-CE3BF2D3686D

P478

Q32003176-391F254D-3284-4710-BCEA-132993845763

P50

Q32003176-603e1da0-4837-cc83-aa60-405851b2066f

P577

Q32003176-17381FB8-4244-42DB-94BD-C81DD894E5D2

P5875

Q32003176-53D9EF20-EC15-4316-960B-B279491A0172

P698

Q32003176-A4E37D60-7F54-4F31-B0E7-4C064C048CC4

P356

JBC.273.42.27364

P1433

Journal of Biological Chemistry

P1476

Definition and redesign of the extended substrate specificity of granzyme B.

@en

P2093

Craik CS

http://www.w3.org/2001/XMLSchema#string

Harris JL

http://www.w3.org/2001/XMLSchema#string

Peterson EP

http://www.w3.org/2001/XMLSchema#string

Thornberry NA

http://www.w3.org/2001/XMLSchema#string

P2860

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

The structure of rat mast cell protease II at 1.9-A resolution

A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

Rapid and efficient site-specific mutagenesis without phenotypic selection

On the size of the active site in proteases. I. Papain

Calculation of protein extinction coefficients from amino acid sequence data

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

P304

27364-27373

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.273.42.27364

http://www.w3.org/2001/XMLSchema#string

P407

P433

42

http://www.w3.org/2001/XMLSchema#string

P478

273

http://www.w3.org/2001/XMLSchema#string

P50

P577

1998-10-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

13521343

http://www.w3.org/2001/XMLSchema#string

P698

9765264

http://www.w3.org/2001/XMLSchema#string