Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily
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Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivoGlycoprotein VI-dependent and -independent pathways of thrombus formation in vivoGlycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation.A novel antiplatelet antibody therapy that induces cAMP-dependent endocytosis of the GPVI/Fc receptor gamma-chain complexDesign, development and characterization of ACT017, a humanized Fab that blocks platelet's glycoprotein VI function without causing bleeding risks.Platelet aggregation inhibitors from hematophagous animals.Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians.Aegyptin, a novel mosquito salivary gland protein, specifically binds to collagen and prevents its interaction with platelet glycoprotein VI, integrin alpha2beta1, and von Willebrand factorVitamin a deficiency and alterations in the extracellular matrix.Inhibition of Glycoprotein VI Clustering by Collagen as a Mechanism of Inhibiting Collagen-Induced Platelet Responses: The Example of Losartan.The influence of N-linked glycosylation on the function of platelet glycoprotein VIConstitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood.A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivoDiscrete role for cytosolic phospholipase A(2)alpha in platelets: studies using single and double mutant mice of cytosolic and group IIA secretory phospholipase A(2).Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice.Salivary antigen-5/CAP family members are Cu2+-dependent antioxidant enzymes that scavenge O₂₋. and inhibit collagen-induced platelet aggregation and neutrophil oxidative burst.Functional expression of IgA receptor FcalphaRI on human platelets.Non-invasive molecular imaging of fibrosis using a collagen-targeted peptidomimetic of the platelet collagen receptor glycoprotein VIRole of cellular elements in thrombus formation and dissolution.Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies.Megakaryocytes compensate for Kit insufficiency in murine arthritis.Inhibition of Collagen-Induced Platelet Aggregation by the Secobutanolide Secolincomolide A from Lindera obtusiloba Blume.Differential Inhibition of Human Atherosclerotic Plaque-Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies.ADPase CD39 Fused to Glycoprotein VI-Fc Boosts Local Antithrombotic Effects at Vascular Lesions.Integrative Systems Biology Investigation of Fabry Disease.Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells.Neutrophil granulocyte-dependent proteolysis enhances platelet adhesion to the arterial wall under high-shear flow.Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti-human platelet agentsMolecular basis for unique specificity of human TRAF4 for platelets GPIbβ and GPVI.The Impact of Helicobacter pylori Urease upon Platelets and Consequent Contributions to Inflammation.Immobilized fibrinogen activates human platelets through glycoprotein VI.Triplatin, a platelet aggregation inhibitor from the salivary gland of the triatomine vector of Chagas disease, binds to TXA(2) but does not interact with glycoprotein PVILocal genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records
P2860
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P2860
Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily
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2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年论文
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name
Cloning, characterization, and ...... the immunoglobulin superfamily
@ast
Cloning, characterization, and ...... the immunoglobulin superfamily
@en
Cloning, characterization, and ...... the immunoglobulin superfamily
@nl
type
label
Cloning, characterization, and ...... the immunoglobulin superfamily
@ast
Cloning, characterization, and ...... the immunoglobulin superfamily
@en
Cloning, characterization, and ...... the immunoglobulin superfamily
@nl
prefLabel
Cloning, characterization, and ...... the immunoglobulin superfamily
@ast
Cloning, characterization, and ...... the immunoglobulin superfamily
@en
Cloning, characterization, and ...... the immunoglobulin superfamily
@nl
P2093
P50
P1433
P1476
Cloning, characterization, and ...... the immunoglobulin superfamily
@en
P2093
Busfield S
Chickering T
Dussault B
Goodearl A
Le Couedic JP
P304
P407
P577
2000-09-01T00:00:00Z