Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice.
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Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human plateletsDefective thrombus formation in mice lacking coagulation factor XIIGlycoprotein VI-dependent and -independent pathways of thrombus formation in vivoRegenerative Therapy of Type 1 Diabetes Mellitus: From Pancreatic Islet Transplantation to Mesenchymal Stem CellsNext-generation antithrombotics in ischemic stroke: preclinical perspective on 'bleeding-free antithrombosis'Aspirin induces platelet receptor shedding via ADAM17 (TACE)A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagenCloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.The GPVI-Fc fusion protein Revacept reduces thrombus formation and improves vascular dysfunction in atherosclerosis without any impact on bleeding timesA novel antiplatelet antibody therapy that induces cAMP-dependent endocytosis of the GPVI/Fc receptor gamma-chain complexCompromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpura.Measuring soluble platelet glycoprotein VI in human plasma by ELISA.Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP.Proteolysis of platelet receptors in humans and other species.Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization.Design, development and characterization of ACT017, a humanized Fab that blocks platelet's glycoprotein VI function without causing bleeding risks.A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.Single domain antibodies against the collagen signalling receptor glycoprotein VI are inhibitors of collagen induced thrombus formation.Targeting GPVI as a novel antithrombotic strategy.Preoperative platelet response to collagen is associated with myocardial injury after off-pump coronary bypass graft in patients taking aspirin.Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation.α2β1 integrin, GPVI receptor, and common FcRγ chain on mouse platelets mediate distinct responses to collagen in models of thrombosisThe GPVI-Fc fusion protein Revacept improves cerebral infarct volume and functional outcome in strokeShear-induced platelet receptor shedding by non-physiological high shear stress with short exposure time: glycoprotein Ibα and glycoprotein VI.Nucleotide-binding oligomerization domain 2 receptor is expressed in platelets and enhances platelet activation and thrombosis.The role of collagen in thrombosis and hemostasis.Platelets in atherothrombosis: lessons from mouse models.Platelets in hemostasis and thrombosis: Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis.A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivoThe Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice.Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challengeFuture innovations in anti-platelet therapies.Platelet integrins and immunoreceptors.Antiplatelet therapy in the era of drug-eluting stents: current and future perspectives.Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal functionThe low-frequency isoform of platelet glycoprotein VIb attenuates ligand-mediated signal transduction but not receptor expression or ligand binding.Alteration of platelet GPVI signaling in ST-elevation myocardial infarction patients demonstrated by a combination of proteomic, biochemical, and functional approaches.Standardizing a simpler, more sensitive and accurate tail bleeding assay in mice.
P2860
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P2860
Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Long-term antithrombotic prote ...... telet glycoprotein VI in mice.
@ast
Long-term antithrombotic prote ...... telet glycoprotein VI in mice.
@en
type
label
Long-term antithrombotic prote ...... telet glycoprotein VI in mice.
@ast
Long-term antithrombotic prote ...... telet glycoprotein VI in mice.
@en
prefLabel
Long-term antithrombotic prote ...... telet glycoprotein VI in mice.
@ast
Long-term antithrombotic prote ...... telet glycoprotein VI in mice.
@en
P2093
P2860
P356
P1476
Long-term antithrombotic prote ...... telet glycoprotein VI in mice.
@en
P2093
B Nieswandt
H Zirngibl
J P Cazenave
K Rackebrandt
R Mokhtari-Nejad
W Bergmeier
P2860
P304
P356
10.1084/JEM.193.4.459
P407
P577
2001-02-01T00:00:00Z