Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation
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WRN interacts physically and functionally with the recombination mediator protein RAD52Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylationWerner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distributionPhysical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factorsKu heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminusRoles of Werner syndrome protein in protection of genome integrityHuman premature aging, DNA repair and RecQ helicasesThe role of RecQ helicases in non-homologous end-joiningRecQ helicases in DNA double strand break repair and telomere maintenance.Regulation of DNA double-strand break repair pathway choiceIdentification and characterization of SMARCAL1 protein complexesRecQ helicases: caretakers of the genomeWRN regulates pathway choice between classical and alternative non-homologous end joiningProteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8.Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1.Acetylation regulates WRN catalytic activities and affects base excision DNA repair.Nonhomologous end joining: a good solution for bad endsConserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding.Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loopsAcetylation of Werner syndrome protein (WRN): relationships with DNA damage, DNA replication and DNA metabolic activities.Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivityDNA repair deficiency in neurodegeneration.WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.Recruitment and retention dynamics of RECQL5 at DNA double strand break sites.Junction of RecQ helicase biochemistry and human disease.Chromatin remodeling, DNA damage repair and aging.Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complexNon-homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process.Telomeres, chromosome instability and cancerCollaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links.Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaksWerner protein cooperates with the XRCC4-DNA ligase IV complex in end-processingRecQ helicases: suppressors of tumorigenesis and premature aging.Structure and function of RecQ DNA helicases.Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation.The life and death of DNA-PK.Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples.
P2860
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P2860
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Werner protein is a target of ...... e regulated by phosphorylation
@ast
Werner protein is a target of ...... e regulated by phosphorylation
@en
Werner protein is a target of ...... e regulated by phosphorylation
@nl
type
label
Werner protein is a target of ...... e regulated by phosphorylation
@ast
Werner protein is a target of ...... e regulated by phosphorylation
@en
Werner protein is a target of ...... e regulated by phosphorylation
@nl
prefLabel
Werner protein is a target of ...... e regulated by phosphorylation
@ast
Werner protein is a target of ...... e regulated by phosphorylation
@en
Werner protein is a target of ...... e regulated by phosphorylation
@nl
P2093
P2860
P3181
P356
P1476
Werner protein is a target of ...... e regulated by phosphorylation
@en
P2093
Carey M Snowden
Jason Piotrowski
Joshua A Sommers
Parimal Karmakar
Robert M Brosh
Susan P Lees Miller
Vilhelm A Bohr
Wen-Hsing Cheng
P2860
P304
18291-18302
P3181
P356
10.1074/JBC.M111523200
P407
P577
2002-03-11T00:00:00Z