Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation
about
Telomere biology: Rationale for diagnostics and therapeutics in cancerTelomerase Regulation from Beginning to the EndATM and ATR Signaling Regulate the Recruitment of Human Telomerase to TelomeresModern genome editing meets telomeres: the many functions of TPP1A balance between elongation and trimming regulates telomere stability in stem cellsContributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase.Human telomerase: biogenesis, trafficking, recruitment, and activation.CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance.Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1.Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactionsTRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.Induced Pluripotent Stem Cells Meet Genome EditingThe Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to TumorigenesisThe Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent Manner.Cancer-associated TERT promoter mutations abrogate telomerase silencingSingle-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes.Cold-inducible RNA-binding protein CIRP/hnRNP A18 regulates telomerase activity in a temperature-dependent manner.Control of telomerase action at human telomeresThe shelterin complex and hematopoiesis.Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenanceStructural and functional consequences of a disease mutation in the telomere protein TPP1.Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In Vivo.Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells.Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation.Means to the ends: The role of telomeres and telomere processing machinery in metastasis.Telomeres in cancer: tumour suppression and genome instability.Telomerase Mechanism of Telomere Synthesis.Control of Cellular Aging, Tissue Function, and Cancer by p53 Downstream of Telomeres.Progress in Human and Tetrahymena Telomerase Structure Determination.Single-Molecule Studies of Telomeres and Telomerase.Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies.p53 Mediates Failure of Human Definitive Hematopoiesis in Dyskeratosis Congenita.Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cellsA loopy view of telomere evolution.DNA-binding determinants and cellular thresholds for human telomerase repeat addition processivity.Fission yeast Ccq1 is a modulator of telomerase activity.Distinct Responses of Stem Cells to Telomere Uncapping-A Potential Strategy to Improve the Safety of Cell Therapy.The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action.
P2860
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P2860
Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation
description
2014 nî lūn-bûn
@nan
2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Genetic and molecular identifi ...... meostasis set point regulation
@ast
Genetic and molecular identifi ...... meostasis set point regulation
@en
Genetic and molecular identifi ...... meostasis set point regulation
@nl
type
label
Genetic and molecular identifi ...... meostasis set point regulation
@ast
Genetic and molecular identifi ...... meostasis set point regulation
@en
Genetic and molecular identifi ...... meostasis set point regulation
@nl
prefLabel
Genetic and molecular identifi ...... meostasis set point regulation
@ast
Genetic and molecular identifi ...... meostasis set point regulation
@en
Genetic and molecular identifi ...... meostasis set point regulation
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Genetic and molecular identifi ...... meostasis set point regulation
@en
P2093
Alec N Sexton
Christine S Lai
Colleen M O'Neil
Fyodor D Urnov
Kathleen Collins
Samuel G Regalado
P2860
P304
P3181
P356
10.1101/GAD.246819.114
P407
P577
2014-09-01T00:00:00Z