Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria
about
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophreniaDISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphismsThe DISC locus in psychiatric illnessA frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorderDISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial traffickingDISC1-binding proteins in neural development, signalling and schizophreniaDISC1: Structure, Function, and Therapeutic Potential for Major Mental IllnessPrimary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases.Neural activations during auditory oddball processing discriminating schizophrenia and psychotic bipolar disorder.Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction.Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiationGenes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illnessDisrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function.A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse.The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brainSequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and brain morphology in schizophrenia: a voxel-based morphometric studyCopy variations in schizophrenia and bipolar disorder.Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia.Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population.Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice.Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead.Mitochondrial involvement in psychiatric disorders.AKT/GSK3 signaling pathway and schizophreniaA t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury.Effect of DISC1 on the P300 waveform in psychosisSchizophrenia: an integrative approach to modelling a complex disorder.DISC1 genetics, biology and psychiatric illnessSchizophrenia in translation: disrupted in schizophrenia (DISC1): integrating clinical and basic findings.Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness.Global association between cortical thinning and white matter integrity reduction in schizophrenia.DISC1 as a therapeutic target for mental illnesses.Progress in defining the biological causes of schizophrenia.The meaning of mitochondrial movement to a neuron's lifeDrug discovery based on genetic and metabolic findings in schizophrenia.A gene expression and systems pathway analysis of the effects of clozapine compared to haloperidol in the mouse brain implicates susceptibility genes for schizophrenia.Disrupted in schizophrenia 1 (DISC1) is a constituent of the mammalian mitochondrial contact site and cristae organizing system (MICOS) complex, and is essential for oxidative phosphorylation.Interaction of DISC1 with the PTB domain of Tensin2.PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1
P2860
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P2860
Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria
description
2004 nî lūn-bûn
@nan
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Disrupted in Schizophrenia 1 ( ...... ntly localizes to mitochondria
@ast
Disrupted in Schizophrenia 1 ( ...... ntly localizes to mitochondria
@en
Disrupted in Schizophrenia 1 ( ...... ntly localizes to mitochondria
@nl
type
label
Disrupted in Schizophrenia 1 ( ...... ntly localizes to mitochondria
@ast
Disrupted in Schizophrenia 1 ( ...... ntly localizes to mitochondria
@en
Disrupted in Schizophrenia 1 ( ...... ntly localizes to mitochondria
@nl
prefLabel
Disrupted in Schizophrenia 1 ( ...... ntly localizes to mitochondria
@ast
Disrupted in Schizophrenia 1 ( ...... ntly localizes to mitochondria
@en
Disrupted in Schizophrenia 1 ( ...... ntly localizes to mitochondria
@nl
P2093
P1476
Disrupted in Schizophrenia 1 ( ...... ntly localizes to mitochondria
@en
P2093
P304
P356
10.1016/J.MCN.2004.01.013
P407
P577
2004-05-01T00:00:00Z