Targeted cancer therapies based on the inhibition of DNA strand break repair - Wikidata - thesis-toulmin - TriplyDB

Targeted cancer therapies based on the inhibition of DNA strand break repair

Targeted cancer therapies based on the inhibition of DNA strand break repair

http://www.wikidata.org/entity/Q28260348

about

Fragile histidine triad protein, WW domain-containing oxidoreductase protein Wwox, and activator protein 2gamma expression levels correlate with basal phenotype in breast cancer Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer Context-Dependent Cell Cycle Checkpoint Abrogation by a Novel Kinase Inhibitor Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents The LKB1-AMPK pathway: metabolism and growth control in tumour suppression Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase.Targeting Ongoing DNA Damage in Multiple Myeloma: Effects of DNA Damage Response Inhibitors on Plasma Cell Survival.Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM).Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells XRCC2 rs3218536 polymorphism decreases the sensitivity of colorectal cancer cells to poly(ADP-ribose) polymerase 1 inhibitor.In vitro non-homologous DNA end joining assays--the 20th anniversary.The DNA-damage response: new molecular insights and new approaches to cancer therapy Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer.A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970 Report from the Radiation Therapy Committee of the Southwest Oncology Group (SWOG): Research Objectives Workshop 2008.Prediction of individual response to anticancer therapy: historical and future perspectives Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.Response of subtype-specific human breast cancer-derived cells to poly(ADP-ribose) polymerase and checkpoint kinase 1 inhibition.Mass spectrometric identification of novel lysine acetylation sites in huntingtin DNA repair: from genome maintenance to biomarker and therapeutic target.Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence.DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy.MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers Molecular targets for tumor radiosensitization.XRCC2 promotes colorectal cancer cell growth, regulates cell cycle progression, and apoptosis Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease.RAD53 is limiting in double-strand break repair and in protection against toxicity associated with ribonucleotide reductase inhibition Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.DNA-PK suppresses a p53-independent apoptotic response to DNA damage ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.Novel clinical trial designs for innovative therapies.Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining.Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells.Sensitization strategies in lung cancer Impaired DNA damage response--an Achilles' heel sensitizing cancer to chemotherapy and radiotherapy.Checkpoint kinase inhibitors: a review of the patent literature.

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P2860

Targeted cancer therapies based on the inhibition of DNA strand break repair

http://www.wikidata.org/entity/Q28260348

description

2007 nî lūn-bûn

@nan

2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Targeted cancer therapies based on the inhibition of DNA strand break repair

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Targeted cancer therapies based on the inhibition of DNA strand break repair

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Targeted cancer therapies based on the inhibition of DNA strand break repair

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type

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Targeted cancer therapies based on the inhibition of DNA strand break repair

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Targeted cancer therapies based on the inhibition of DNA strand break repair

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Targeted cancer therapies based on the inhibition of DNA strand break repair

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Targeted cancer therapies based on the inhibition of DNA strand break repair

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Targeted cancer therapies based on the inhibition of DNA strand break repair

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Targeted cancer therapies based on the inhibition of DNA strand break repair

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Targeted cancer therapies based on the inhibition of DNA strand break repair

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G C M Smith

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M J O'Connor

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N M B Martin

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P2860

Instability and decay of the primary structure of DNA

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining

Isolation of a small molecule inhibitor of DNA base excision repair.

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

Checkpoints: controls that ensure the order of cell cycle events

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Genome maintenance mechanisms for preventing cancer

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10.1038/SJ.ONC.1210879

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