TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
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Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linkingTARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43Structural insights into TDP-43 in nucleic-acid binding and domain interactionsTDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicingNeuropathology of non-Alzheimer degenerative disordersThe extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivoDysregulated axonal RNA translation in amyotrophic lateral sclerosisImmunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction networkImpaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron DegenerationNeuroplasticity and Repair in Rodent Neurotoxic Models of Spinal Motoneuron DiseaseFrontotemporal Lobar Degeneration and MicroRNAsConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisThe function of RNA-binding proteins at the synapse: implications for neurodegenerationTherapeutic and diagnostic challenges for frontotemporal dementiaMitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?Hyperphosphorylation as a defense mechanism to reduce TDP-43 aggregationMolecular basis of UG-rich RNA recognition by the human splicing factor TDP-43TDP-43 aggregation in neurodegeneration: are stress granules the key?Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissueThe Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress.Proteomic Analysis of Dynein-Interacting Proteins in Amyotrophic Lateral Sclerosis Synaptosomes Reveals Alterations in the RNA-Binding Protein Staufen1.The sour side of neurodegenerative disorders: the effects of protein glycation.VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death.Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6miRNA malfunction causes spinal motor neuron disease.The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants.Astrocytic TDP-43 pathology in Alexander diseaseCytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis.Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression.The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanismThe role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia.TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.Neuronal function and dysfunction of Drosophila dTDPElevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination
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P2860
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
@ast
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
@en
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
@nl
type
label
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
@ast
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
@en
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
@nl
prefLabel
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
@ast
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
@en
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
@nl
P2093
P2860
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P1476
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
@en
P2093
C-K James Shen
Hsiang-Yu Chang
I-Fan Wang
Lien-Szn Wu
P2860
P304
P3181
P356
10.1111/J.1471-4159.2007.05190.X
P407
P577
2008-05-01T00:00:00Z