Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.
about
P1343
TDP-35 sequesters TDP-43 into cytoplasmic inclusions through binding with RNAInside out: the role of nucleocytoplasmic transport in ALS and FTLDMechanisms of FUS mutations in familial amyotrophic lateral sclerosisDysregulated axonal RNA translation in amyotrophic lateral sclerosisAlterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?Modeling ALS and FTD with iPSC-derived neuronsAxonal transport: cargo-specific mechanisms of motility and regulationiPSC-Based Models to Unravel Key Pathogenetic Processes Underlying Motor Neuron Disease DevelopmentThe function of RNA-binding proteins at the synapse: implications for neurodegenerationRNA-binding proteins in neurodegeneration: Seq and you shall receiveNeurodegeneration behind bars: from molecules to jurisprudenceTracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA GranulesRNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress responseA Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During DiseaseA perspective on stem cell modeling of amyotrophic lateral sclerosisTDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the diseaseAre aberrant phase transitions a driver of cellular aging?Proteomic Analysis of Dynein-Interacting Proteins in Amyotrophic Lateral Sclerosis Synaptosomes Reveals Alterations in the RNA-Binding Protein Staufen1.Structure-function integrity of the adult hippocampus depends on the transcription factor Bcl11b/Ctip2.In the right place at the right time: visualizing and understanding mRNA localization.Gene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegeneration.Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD.RNA metabolism in neurodegenerative disease.Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms.Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation.CGG repeats in RNA modulate expression of TDP-43 in mouse and fly models of fragile X tremor ataxia syndromePresynaptic localization of Smn and hnRNP R in axon terminals of embryonic and postnatal mouse motoneuronsIn vivo imaging of axonal transport in murine motor and sensory neurons.Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease.Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis.Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathiesAberrant RNA homeostasis in amyotrophic lateral sclerosis: potential for new therapeutic targets?Targeting axonal protein synthesis in neuroregeneration and degeneration.Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viabilityA fruitful endeavor: modeling ALS in the fruit flyLinking RNA Dysfunction and Neurodegeneration in Amyotrophic Lateral Sclerosis.Single-molecule insights into mRNA dynamics in neurons.Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.
P2860
Q24338199-694645A9-35C2-411F-954E-E587D062AB50Q26748482-EE97F732-76D2-4587-8FBB-15952022857FQ26749169-BBF5F71F-42EA-4365-9A23-ED69D86874DAQ26753110-4BC6BB65-057F-43D0-8342-7591498CED42Q26777971-7428CE84-7F10-4DFF-B7A7-F74ECB28CA1EQ26783672-149718F5-A736-435F-B078-8FFB67CDBFB2Q26827748-058C8160-D3DB-43B4-8B14-0E105278ACB7Q26863612-AE05A0D8-2275-4AE0-AA69-DC37221CAA8EQ26991684-2188FEFD-1850-411C-B87E-2F828E9FF4C8Q27000416-4852BE7F-4F46-451A-8FF2-525BA149EB84Q27015989-899C9938-4C7B-4883-803B-DAD992AFB45DQ27308310-6D818FAB-5AFE-4B29-8ACB-5A864DC4D4C1Q27312567-AE56A81D-1B1F-49B0-AFD3-5BE1ADB8C598Q28079299-E6AF62F7-EB07-44AB-8518-72853D349001Q28080614-9D94B141-B85C-4BB7-BE23-60FE134243C1Q28080628-AF42351B-3710-4313-908E-D6C8F87A1961Q28392297-22085D61-688A-482F-AABC-E50B4E1CCCE8Q28821465-595E0258-6A65-4D37-A508-7A8A863D90F7Q30354368-0C897A85-779C-4533-9371-81BA16903E39Q30385529-56C7B675-708B-4224-B676-E8BCE4F7231FQ30656002-98D1BA5C-B1C9-4369-A969-0B4B10E9C2DAQ30659873-BAEF619A-C569-4A72-B53E-3EC1F491CA53Q33614771-E26D80CA-079E-4EB1-81A3-C5E4BAE74020Q33746283-158BF5B5-B446-401C-8872-5D4D74FEE814Q34155410-B41D8245-D3FA-4DCA-896C-DB5D219808F5Q34363918-5D65B483-7F29-4768-A4A9-E5F188A61CD6Q34379046-3B913754-7BB7-4DE3-B7B6-8AF9B5DFD1E0Q34388403-A67A303B-AB38-434A-B07A-B6E42D649C55Q34496397-6D806975-8FA2-4F7A-BBB6-FDF0702E8F7FQ34525808-DAC7EE3D-7BC5-42F0-931A-09D496C4292FQ34557892-12402B63-C3FF-42D2-86C0-32C0429AE548Q34573377-F280B917-17BA-4CD3-87E6-6810F3D52D87Q34983534-8EFE6FC0-39B0-4C81-BEA6-6591593E45FFQ35019375-542815DC-CF18-4B9C-A25C-B63F8033B6CAQ35064944-44D0255B-A202-4123-9C3D-E8F0820B0EC8Q35114316-E281F076-79D8-49CF-AA0D-E33928ACE0A0Q35268719-D4B547FD-DA3A-40D5-8841-87340396251EQ35501802-6EFA635C-3CF2-42E6-9619-EBBF4E481787Q35889984-2C1E93BB-E97C-45FB-9427-A66BEE7C8250Q35910495-4C22F2EC-4785-4530-A087-A1A16C268CB0
P2860
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.
description
2014 nî lūn-bûn
@nan
2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
name
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.
@ast
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.
@en
type
label
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.
@ast
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.
@en
prefLabel
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.
@ast
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.
@en
P2093
P2860
P1433
P1476
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.
@en
P2093
Alison J Clare
Anderson Kanagaraj
Bilada Bilican
Brett Winborn
Brian D Freibaum
Christina S Winborn
Christopher E Shaw
Edward Chaum
Evangelos Kiskinis
Kevin C Eggan
P2860
P304
P356
10.1016/J.NEURON.2013.12.018
P407
P577
2014-02-01T00:00:00Z