Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases
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Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinaseSrc family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progressionCbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiationIdentification and functional characterization of an Src homology domain 3 domain-binding site on CblMolecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinaseAPS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytesDefective T cell receptor-mediated signal transduction in memory CD4 T lymphocytes exposed to superantigen or anti-T cell receptor antibodiesThe ubiquitin/proteasome system mediates entry and endosomal trafficking of Kaposi's sarcoma-associated herpesvirus in endothelial cellsStructure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinaseSystematic approaches to identify E3 ligase substratesThe involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activationVav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyteThe Cbl interactome and its functionsCbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cellsPhosphorylation of Syk activation loop tyrosines is essential for Syk function. An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibodyNegative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activationThe Syk family of protein tyrosine kinases in T-cell activation and developmentA dynamic view of domain-motif interactions.Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding.Suppression of apoptosis induced by growth factor withdrawal by an oncogenic form of c-Cbl.Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl.Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells.Signaling pathways in phagocytosis.c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway.The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.Tyrosines in the carboxyl terminus regulate Syk kinase activity and functionCbl: many adaptations to regulate protein tyrosine kinases.Src kinase and Syk activation initiate PI3K signaling by a chimeric latent membrane protein 1 in Epstein-Barr virus (EBV)+ B cell lymphomas.Beyond the RING: CBL proteins as multivalent adapters.Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways.A PKC-SHP1 signaling axis desensitizes Fcγ receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcγR mediated phagocytosis.Tyrosine phosphorylated c-Cbl regulates platelet functional responses mediated by outside-in signalingSuperantigen-induced CD4 memory T cell anergy. I. Staphylococcal enterotoxin B induces Fyn-mediated negative signalingAnergy in CD4 memory T lymphocytes. II. Abrogation of TCR-induced formation of membrane signaling complexesActivating Mutations in PIK3CA Lead to Widespread Modulation of the Tyrosine Phosphoproteome.Targeting the Spleen Tyrosine Kinase with Fostamatinib as a Strategy against Waldenström Macroglobulinemia.c-Cbl expression levels regulate the functional responses of human central and effector memory CD4 T cellsSyk and pTyr'd: Signaling through the B cell antigen receptor
P2860
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P2860
Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases
description
1998 nî lūn-bûn
@nan
1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Coordinated regulation of the ...... y Fyn and Syk tyrosine kinases
@ast
Coordinated regulation of the ...... y Fyn and Syk tyrosine kinases
@en
Coordinated regulation of the ...... y Fyn and Syk tyrosine kinases
@nl
type
label
Coordinated regulation of the ...... y Fyn and Syk tyrosine kinases
@ast
Coordinated regulation of the ...... y Fyn and Syk tyrosine kinases
@en
Coordinated regulation of the ...... y Fyn and Syk tyrosine kinases
@nl
prefLabel
Coordinated regulation of the ...... y Fyn and Syk tyrosine kinases
@ast
Coordinated regulation of the ...... y Fyn and Syk tyrosine kinases
@en
Coordinated regulation of the ...... y Fyn and Syk tyrosine kinases
@nl
P2093
P2860
P3181
P356
P1476
Coordinated regulation of the ...... y Fyn and Syk tyrosine kinases
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.273.15.8867
P407
P50
P577
1998-04-01T00:00:00Z