Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms - Wikidata - thesis-toulmin - TriplyDB

Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms

Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms

http://www.wikidata.org/entity/Q28292633

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Cancer stem cells: relevance to clinical transplantation Intratibial injection of human multiple myeloma cells in NOD/SCID IL-2Rγ(null) mice mimics human myeloma and serves as a valuable tool for the development of anticancer strategies Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms.Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells.Telomerase contributes to fludarabine resistance in primary human leukemic lymphocytes.Imetelstat, a telomerase inhibitor, differentially affects normal and malignant megakaryopoiesis.Implications of heterogeneity in multiple myeloma.The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation Transcriptional coactivator CBP upregulates hTERT expression and tumor growth and predicts poor prognosis in human lung cancers High throughput quantitative reverse transcription PCR assays revealing over-expression of cancer testis antigen genes in multiple myeloma stem cell-like side population cells.Expression profile of telomere-associated genes in multiple myeloma.Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage Concise review: Emerging concepts in clinical targeting of cancer stem cells Targeting telomerase-expressing cancer cells.Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma Prospective analysis of antigen-specific immunity, stem-cell antigens, and immune checkpoints in monoclonal gammopathy.The telomerase inhibitor imetelstat alone, and in combination with trastuzumab, decreases the cancer stem cell population and self-renewal of HER2+ breast cancer cells Model of translational cancer research in multiple myeloma.Multiple myeloma cells expressing low levels of CD138 have an immature phenotype and reduced sensitivity to lenalidomide.Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1 Therapeutic strategies targeting cancer stem cells Clonogenic multiple myeloma cells have shared stemness signature associated with patient survival The role of SH3GL3 in myeloma cell migration/invasion, stemness and chemo-resistance.The genetic architecture of multiple myeloma.Cancer stem cells: the development of new cancer therapeutics.Histone deacetylase inhibition as an anticancer telomerase-targeting strategy.Is telomerase a viable target in cancer?Autologous stem cell transplantation and multiple myeloma cancer stem cells.Telomere dysfunction and its role in haematological cancer.Preclinical models of multiple myeloma: a critical appraisal.Concise review: Defining and targeting myeloma stem cell-like cells.Identify multiple myeloma stem cells: Utopia?Hypoxia reduces CD138 expression and induces an immature and stem cell-like transcriptional program in myeloma cells.Small molecule antibody targeting HLA class I inhibits myeloma cancer stem cells by repressing pluripotency-associated transcription factors.CD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype.Identifying the biomarker potential of telomerase activity and shelterin complex molecule, telomeric repeat binding factor 2 (TERF2), in multiple myeloma.

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Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms

http://www.wikidata.org/entity/Q28292633

description

2010 nî lūn-bûn

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2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Telomerase inhibition targets ...... ent and independent mechanisms

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Telomerase inhibition targets ...... ent and independent mechanisms

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Telomerase inhibition targets ...... ent and independent mechanisms

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type

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Telomerase inhibition targets ...... ent and independent mechanisms

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Telomerase inhibition targets ...... ent and independent mechanisms

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Telomerase inhibition targets ...... ent and independent mechanisms

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Telomerase inhibition targets ...... ent and independent mechanisms

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Telomerase inhibition targets ...... ent and independent mechanisms

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Telomerase inhibition targets ...... ent and independent mechanisms

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Telomerase inhibition targets ...... ent and independent mechanisms

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Calvin Harley

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Carol Ann Huff

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Ekaterina Bassett

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Ning Go

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Qiuju Wang

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Richard J Jones

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Robert Tressler

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Sarah K Brennan

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P2860

Telomerase modulates Wnt signalling by association with target gene chromatin

Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

Characterization of clonogenic multiple myeloma cells

Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance

The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells

Induced pluripotent stem cell lines derived from human somatic cells

Specific association of human telomerase activity with immortal cells and cancer

Stem cells, cancer, and cancer stem cells

The RNA component of human telomerase

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telomere length

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