SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
about
Function, regulation and pathological roles of the Gab/DOS docking proteinsSerine phosphorylation by SYK is critical for nuclear localization and transcription factor function of IkarosGerminal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activationSequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cellsThe kinase Syk as an adaptor controlling sustained calcium signalling and B-cell developmentCooperative interactions at the SLP-76 complex are critical for actin polymerizationSLP-65 signal transduction requires Src homology 2 domain-mediated membrane anchoring and a kinase-independent adaptor function of SykSCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signalingThe kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cellsT cell activationCoactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapseImidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free-Energy Perturbation (FEP)SLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteinsIntegrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifsGenome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility lociGrb2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner.Mechanism and function of Vav1 localisation in TCR signalling.SH2-dependent autophosphorylation within the Tec family kinase Itk.T cell antigen receptor signaling and immunological synapse stability require myosin IIATyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways.BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cellsAdaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells.T-cell artificial focal triggering tools: linking surface interactions with cell response.Implication of vascular endothelial growth factor A and C in revealing diagnostic lymphangiogenic markers in node-positive bladder cancer.Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strainNovel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease courseT-cell signaling regulated by the Tec family kinase, Itk.Spatial association of signaling proteins and F-actin effects on cluster assembly analyzed via photoactivation localization microscopy in T cellsSignaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cellsMislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody productionHIV-1 Nef: a multifaceted modulator of T cell receptor signaling.Pregnancy induces transcriptional activation of the peripheral innate immune system and increases oxidative DNA damage among healthy third trimester pregnant women.Adapters in the organization of mast cell signaling.Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.BANK1 and BLK act through phospholipase C gamma 2 in B-cell signalingThe pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.Itk: the rheostat of the T cell response.The requirements for natural Th17 cell development are distinct from those of conventional Th17 cells
P2860
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P2860
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
@ast
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
@en
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
@nl
type
label
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
@ast
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
@en
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
@nl
prefLabel
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
@ast
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
@en
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
@nl
P2093
P2860
P3181
P356
P1476
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
@en
P2093
Farhad Abtahian
Gary A Koretzky
Michael A Silverman
P2860
P2888
P3181
P356
10.1038/NRI1750
P407
P577
2006-01-01T00:00:00Z
P6179
1001692527