Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunit
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Neurosteroids: endogenous role in the human brain and therapeutic potentialsGABAergic neuroactive steroids: a new frontier in bipolar disorders?Influence of membrane cholesterol on modulation of the GABA(A) receptor by neuroactive steroids and other potentiatorsModulation of GABA(A) receptor channel gating by pentobarbitalSignal transduction of pregnenolone sulfate in insulinoma cells: activation of Egr-1 expression involving TRPM3, voltage-gated calcium channels, ERK, and ternary complex factorsThe Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate ReceptorsSteroid modulation of GABAA receptor-mediated transmission in the hypothalamus: effects on reproductive function.Structurally diverse amphiphiles exhibit biphasic modulation of GABAA receptors: similarities and differences with neurosteroid actions.Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies.Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity.Drug safety is a barrier to the discovery and development of new androgen receptor antagonists.Waking action of ursodeoxycholic acid (UDCA) involves histamine and GABAA receptor block.Pregnenolone sulfate increases glutamate release at neonatal climbing fiber-to-Purkinje cell synapsesNeurosteroid biosynthesis downregulation and changes in GABAA receptor subunit composition: A biomarker axis in stress-induced cognitive and emotional impairment.Rapid neuromodulation by cortisol in the rat paraventricular nucleus: an in vitro studyResidues in the first transmembrane domain of the Caenorhabditis elegans GABA(A) receptor confer sensitivity to the neurosteroid pregnenolone sulfate.Hydrophobic anions potently and uncompetitively antagonize GABA(A) receptor function in the absence of a conventional binding sitePhosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function.Neurosteroids and GABA-A Receptor Function.Mechanisms of neurosteroid interactions with GABA(A) receptors.Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetatealpha1beta2delta, a silent GABAA receptor: recruitment by tracazolate and neurosteroids.Neurosteroids, stress and depression: potential therapeutic opportunities.Effects on membrane capacitance of steroids with antagonist properties at GABAA receptorsThe insecticide fipronil and its metabolite fipronil sulphone inhibit the rat alpha1beta2gamma2L GABA(A) receptor.Role of hormones and neurosteroids in epileptogenesis.Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability.The benzodiazepine diazepam potentiates responses of α1β2γ2L γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists.Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation.The influence of the membrane on neurosteroid actions at GABA(A) receptors.Progesterone and its metabolites as therapeutic targets in psychiatric disorders.A mutant residue in the third transmembrane region of the GABA(A) alpha1 subunit causes increased agonistic neurosteroid responses.Activation and modulation of concatemeric GABA-A receptors expressed in human embryonic kidney cells.Mechanisms of anabolic androgenic steroid inhibition of mammalian epsilon-subunit-containing GABAA receptors.Neuroactive steroids have multiple actions to potentiate GABAA receptors.Inhibition of the GABAA Receptor by Sulfated Neurosteroids: A Mechanistic Comparison Study between Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate.Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit.Activation-dependent properties of pregnenolone sulfate inhibition of GABAA receptor-mediated current.
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P2860
Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunit
description
2001 nî lūn-bûn
@nan
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Pregnenolone sulfate block of ...... M2 region of the alpha subunit
@ast
Pregnenolone sulfate block of ...... M2 region of the alpha subunit
@en
Pregnenolone sulfate block of ...... M2 region of the alpha subunit
@nl
type
label
Pregnenolone sulfate block of ...... M2 region of the alpha subunit
@ast
Pregnenolone sulfate block of ...... M2 region of the alpha subunit
@en
Pregnenolone sulfate block of ...... M2 region of the alpha subunit
@nl
prefLabel
Pregnenolone sulfate block of ...... M2 region of the alpha subunit
@ast
Pregnenolone sulfate block of ...... M2 region of the alpha subunit
@en
Pregnenolone sulfate block of ...... M2 region of the alpha subunit
@nl
P2093
P2860
P1476
Pregnenolone sulfate block of ...... M2 region of the alpha subunit
@en
P2093
J Bracamontes
J H Steinbach
P2860
P304
P356
10.1111/J.1469-7793.2001.0673E.X
P407
P577
2001-05-01T00:00:00Z