Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
about
Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CARCross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factorsGenomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genomeIdentification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearanceEndogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C diseaseThe biological actions of dehydroepiandrosterone involves multiple receptorsInhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complexAlternatively spliced isoforms of the human constitutive androstane receptorInduction of bilirubin clearance by the constitutive androstane receptor (CAR)Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).Understanding the human health effects of chemical mixtures.Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).Modulation of xenobiotic receptors by steroidsTargeting xenobiotic receptors PXR and CAR in human diseasesMarine invertebrate xenobiotic-activated nuclear receptors: their application as sensor elements in high-throughput bioassays for marine bioactive compoundsConversion of Human Steroid 5 -Reductase (AKR1D1) into 3 -Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERINGActivation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional stateNuclear receptor response elements mediate induction of intestinal MDR1 by rifampinIdentification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genesInhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gammaCREBH determines the severity of sulpyrine-induced fatal shockStructural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptorTransactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) ActivationEvolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile saltsEvolution and medicine: the long reach of "Dr. Darwin"Endocrine-disrupting chemicals and fatty liver disease.Retinoic acid actions through mammalian nuclear receptors.The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors.Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR).Cytochrome P450 CYP2 genes in the common cormorant: Evolutionary relationships with 130 diapsid CYP2 clan sequences and chemical effects on their expressionA comparison of machine learning algorithms for chemical toxicity classification using a simulated multi-scale data model.A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.Phenobarbital Meets Phosphorylation of Nuclear ReceptorsMode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activatorEvolutionary history and functional characterization of the amphibian xenosensor CAR.The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptorIdentification of clinically used drugs that activate pregnane X receptorsActivation of xenobiotic receptors: driving into the nucleus.On the general mechanism of selective induction of cytochrome P450 enzymes by chemicals: some theoretical considerations.
P2860
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P2860
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
description
2000 nî lūn-bûn
@nan
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Orphan nuclear receptors const ...... xenobiotic and steroid ligands
@ast
Orphan nuclear receptors const ...... xenobiotic and steroid ligands
@en
Orphan nuclear receptors const ...... xenobiotic and steroid ligands
@nl
type
label
Orphan nuclear receptors const ...... xenobiotic and steroid ligands
@ast
Orphan nuclear receptors const ...... xenobiotic and steroid ligands
@en
Orphan nuclear receptors const ...... xenobiotic and steroid ligands
@nl
prefLabel
Orphan nuclear receptors const ...... xenobiotic and steroid ligands
@ast
Orphan nuclear receptors const ...... xenobiotic and steroid ligands
@en
Orphan nuclear receptors const ...... xenobiotic and steroid ligands
@nl
P2093
P2860
P3181
P356
P1476
Orphan nuclear receptors const ...... xenobiotic and steroid ligands
@en
P2093
J B Stimmel
J L Collins
R K Bledsoe
S A Kliewer
S G Blanchard
P2860
P304
P3181
P356
10.1074/JBC.M001215200
P407
P577
2000-05-19T00:00:00Z