Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo - Wikidata - thesis-toulmin - TriplyDB

Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo

Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo

http://www.wikidata.org/entity/Q28383769

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PSMA-specific CAR-engineered T cells eradicate disseminated prostate cancer in preclinical models Development of an inducible caspase-9 safety switch for pluripotent stem cell-based therapies Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector Delivery of full-length factor VIII using a piggyBac transposon vector to correct a mouse model of hemophilia A.Lentiviral vector-based insertional mutagenesis identifies genes involved in the resistance to targeted anticancer therapies.Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras.Autologous skeletal muscle derived cells expressing a novel functional dystrophin provide a potential therapy for Duchenne Muscular Dystrophy.Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease.Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the β(A(T87Q))-Globin Gene.A comparison of foamy and lentiviral vector genotoxicity in SCID-repopulating cells shows foamy vectors are less prone to clonal dominance.Dimethyloxaloylglycine increases bone repair capacity of adipose-derived stem cells in the treatment of osteonecrosis of the femoral head.Pervasive supply of therapeutic lysosomal enzymes in the CNS of normal and Krabbe-affected non-human primates by intracerebral lentiviral gene therapy Lentiviral hematopoietic stem cell gene therapy in inherited metabolic disorders.Integration site and clonal expansion in human chronic retroviral infection and gene therapy.Alpharetroviral vectors: from a cancer-causing agent to a useful tool for human gene therapy.Cartilage tissue engineering: recent advances and perspectives from gene regulation/therapy.CRISPR genome engineering and viral gene delivery: a case of mutual attraction.Recent trends in the gene therapy of β-thalassemia.Gene therapy and peripheral nerve repair: a perspective.Evidence for the in vivo safety of insulated foamy viral vectors Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector Viral vectors for therapy of neurologic diseases.Viral Vectors: The Road to Reducing Genotoxicity.Insulated Foamy Viral Vectors.A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells.Retroviral vector interactions with hematopoietic cells.Gene delivery to rat and human Schwann cells and nerve segments: a comparison of AAV 1-9 and lentiviral vectors.HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells.Tightly regulated 'all-in-one' lentiviral vectors for protection of human hematopoietic cells from anticancer chemotherapy.Long-Term Restoration of Thymidine Phosphorylase Function and Nucleoside Homeostasis Using Hematopoietic Gene Therapy in a Murine Model of Mitochondrial Neurogastrointestinal Encephalomyopathy.Genome Editing of the Blood: Opportunities and Challenges Highly efficient retinal gene delivery with helper-dependent adenoviral vectors.CCR5 Gene Editing of Resting CD4(+) T Cells by Transient ZFN Expression From HIV Envelope Pseudotyped Nonintegrating Lentivirus Confers HIV-1 Resistance in Humanized Mice VISPA: a computational pipeline for the identification and analysis of genomic vector integration sites.Hematopoietic Stem Cell Gene Therapy: Progress and Lessons Learned.Analyzing the Genotoxicity of Retroviral Vectors in Hematopoietic Cell Gene Therapy.Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients.Improved calvarial bone repair by hASCs engineered with Cre/loxP-based baculovirus conferring prolonged BMP-2 and MiR-148b co-expression.Targeted in vivo knock-in of human alpha-1-antitrypsin cDNA using adenoviral delivery of CRISPR/Cas9.Clinical use of lentiviral vectors.

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Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo

http://www.wikidata.org/entity/Q28383769

description

2014 nî lūn-bûn

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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2014 թվականի ապրիլին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Molecular Therapy

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Fabrizio Benedicenti

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P2860

Mutational activation of the MAP3K8 protooncogene in lung cancer

Structure and transforming potential of the human cot oncogene encoding a putative protein kinase

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer.

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

Pten is essential for embryonic development and tumour suppression

Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

RNA polymerase II and the integration of nuclear events

RNA polymerase II is an essential mRNA polyadenylation factor

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Christof von Kalle

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259807970

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