The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism - Wikidata - thesis-toulmin - TriplyDB

The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

http://www.wikidata.org/entity/Q28392347

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Update on the Kelch-like (KLHL) gene family Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance Mechanisms of omega-3 polyunsaturated fatty acids in prostate cancer prevention Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad HER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interaction Mechanisms of Nrf2/Keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates Comparative analysis of NRF2-responsive gene expression in AcPC-1 pancreatic cancer cell line Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2 Causes of genome instability: the effect of low dose chemical exposures in modern society Kaposi's sarcoma-associated herpesvirus induces Nrf2 activation in latently infected endothelial cells through SQSTM1 phosphorylation and interaction with polyubiquitinated Keap1 BRCA1 and Oxidative Stress Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications Cytoprotection "gone astray": Nrf2 and its role in cancer Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine Kaposi's sarcoma-associated herpesvirus induces Nrf2 during de novo infection of endothelial cells to create a microenvironment conducive to infection G-Quadruplex in the NRF2 mRNA 5' Untranslated Region Regulates De Novo NRF2 Protein Translation under Oxidative Stress CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation The sensitivity of cancer cells to pheophorbide a-based photodynamic therapy is enhanced by Nrf2 silencing Nrf2 enhances cholangiocyte expansion in Pten-deficient livers Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma.The succinated proteome.The roles of microRNA families in hepatic fibrosis.Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis.Keap1 modulates the redox cycle and hepatocyte cell cycle in regenerating liver.Iron and thiols as two major players in carcinogenesis: friends or foes?Nrf2 is involved in maintaining hepatocyte identity during liver regeneration.Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties.The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies Altered gene expression patterns during the initiation and promotion stages of neonatally diethylstilbestrol-induced hyperplasia/dysplasia/neoplasia in the hamster uterus.Reduced polymorphism in the Kelch propeller domain in Plasmodium vivax isolates from Cambodia.Nrf2 is essential for timely M phase entry of replicating hepatocytes during liver regeneration.Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus.Lutein has a protective effect on hepatotoxicity induced by arsenic via Nrf2 signaling.Benefits and risks of the hormetic effects of dietary isothiocyanates on cancer prevention.

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The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

http://www.wikidata.org/entity/Q28392347

description

2012 nî lūn-bûn

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2012 թուականին հրատարակուած գիտական յօդուած

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2012 թվականին հրատարակված գիտական հոդված

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2012年の論文

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2012年学术文章

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2012年學術文章

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name

The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

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The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

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The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

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The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

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The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

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The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

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The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

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The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

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The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

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FONC.2012.00200

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Frontiers in Oncology

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The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

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Hozumi Motohashi

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Masayuki Yamamoto

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Yoichiro Mitsuishi

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Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2

The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

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200

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scholarly article

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2174019

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10.3389/FONC.2012.00200

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234000449

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23272301

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3530133

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