Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice
about
Transcription promotes contraction of CAG repeat tracts in human cellsFragile X syndrome: the FMR1 CGG repeat distribution among world populationsDNA slip-outs cause RNA polymerase II arrest in vitro: potential implications for genetic instabilityCAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroupDNA mismatch repair: molecular mechanism, cancer, and ageingComparative genomics and molecular dynamics of DNA repeats in eukaryotesMechanistic features of CAG*CTG repeat contractions in cultured cells revealed by a novel genetic assayInverted repeat-stimulated sister-chromatid exchange events are RAD1-independent but reduced in a msh2 mutant.Advances in mechanisms of genetic instability related to hereditary neurological diseases.DNA triplet repeat expansion and mismatch repairRepeat-mediated genetic and epigenetic changes at the FMR1 locus in the Fragile X-related disordersGenetics and neuropathology of Huntington's diseaseSuppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington’s DiseaseA universal mechanism ties genotype to phenotype in trinucleotide diseasesContinuous and periodic expansion of CAG repeats in Huntington's disease R6/1 miceMolecular genetics and genetic testing in myotonic dystrophy type 1.The 26S proteasome drives trinucleotide repeat expansionsIdentification of RTG2 as a modifier gene for CTG*CAG repeat instability in Saccharomyces cerevisiaeExpansion, mosaicism and interruption: mechanisms of the CAG repeat mutation in spinocerebellar ataxia type 1Ups and Downs: Mechanisms of Repeat Instability in the Fragile X-Related DisordersThe fragile X gene and its functionMechanisms and consequences of somatic mosaicism in humansMechanisms and functions of DNA mismatch repairStructural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesRole of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesisA novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's diseaseLocalization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase IPms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissuesOnset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability.MutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)n or (CTG)n hairpins for error-prone DNA synthesisIncision-dependent and error-free repair of (CAG)(n)/(CTG)(n) hairpins in human cell extractsIsolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired.Somatic CTG*CAG repeat instability in a mouse model for myotonic dystrophy type 1 is associated with changes in cell nuclearity and DNA ploidy.Huntington disease expansion mutations in humans can occur before meiosis is completed.Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic miceMSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells.Progressive GAA.TTC repeat expansion in human cell lines.A novel approach to investigate tissue-specific trinucleotide repeat instability.Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes
P2860
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P2860
Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice
description
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
articolo scientifico
@it
artículu científicu espublizáu en 1999
@ast
im Dezember 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/12/01)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/12/01)
@nl
наукова стаття, опублікована в грудні 1999
@uk
name
Msh2 deficiency prevents in vi ...... ington disease transgenic mice
@ast
Msh2 deficiency prevents in vi ...... ington disease transgenic mice
@en
Msh2 deficiency prevents in vi ...... ington disease transgenic mice
@nl
type
label
Msh2 deficiency prevents in vi ...... ington disease transgenic mice
@ast
Msh2 deficiency prevents in vi ...... ington disease transgenic mice
@en
Msh2 deficiency prevents in vi ...... ington disease transgenic mice
@nl
prefLabel
Msh2 deficiency prevents in vi ...... ington disease transgenic mice
@ast
Msh2 deficiency prevents in vi ...... ington disease transgenic mice
@en
Msh2 deficiency prevents in vi ...... ington disease transgenic mice
@nl
P2093
P3181
P356
P1433
P1476
Msh2 deficiency prevents in vi ...... ington disease transgenic mice
@en
P2093
L. Flaherty
T. L. Shirley
P2888
P304
P3181
P356
10.1038/70598
P407
P577
1999-12-01T00:00:00Z
P5875
P6179
1028338403