Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
about
RAG1 core and V(D)J recombination signal sequences were derived from Transib transposonsAmino acid residues in RAG1 responsible for the interaction with RAG2 during the V(D)J recombination processAn ancient evolutionary origin of the Rag1/2 gene locusBiochemical characterization of a SET and transposase fusion protein, Metnase: its DNA binding and DNA cleavage activityThe recombination activation gene 1 (Rag1) is expressed in a subset of zebrafish olfactory neurons but is not essential for axon targeting or amino acid detection.Long-Range Regulation of V(D)J RecombinationRetroviral Integrase: Then and NowCoordination of divalent metal ions in the active site of poly(A)-specific ribonucleaseIdentification of the active site of poly(A)-specific ribonuclease by site-directed mutagenesis and Fe(2+)-mediated cleavageThe active site of the DNA repair endonuclease XPF-ERCC1 forms a highly conserved nuclease motif.Putting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1Recombination-activating gene proteins: more regulation, pleaseThe taming of a transposon: V(D)J recombination and the immune systemHuman RAG mutations: biochemistry and clinical implicationsRAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin lociAutoubiquitylation of the V(D)J recombinase protein RAG1Compound heterozygous mutation of Rag1 leading to Omenn syndromeA WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactionsAdapting to a changing world: RAG genomics and evolutionFunctional characterization of an active Rag-like transposaseMapping and Quantitation of the Interaction between the Recombination Activating Gene Proteins RAG1 and RAG2.Crystal structure of the V(D)J recombinase RAG1-RAG2Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid bindingSelf-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase.Thermal dependency of RAG1 self-association properties.Mutational analysis of highly conserved aspartate residues essential to the catalytic core of the piggyBac transposaseThe origins of the Rag genes--from transposition to V(D)J recombination.A green fluorescent protein solubility screen in E. coli reveals domain boundaries of the GTP-binding domain in the P element transposase.Analysis of mutations from SCID and Omenn syndrome patients reveals the central role of the Rag2 PHD domain in regulating V(D)J recombination.A family of developmentally excised DNA elements in Tetrahymena is under selective pressure to maintain an open reading frame encoding an integrase-like proteinNon-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.Effect of HIV integrase inhibitors on the RAG1/2 recombinase.Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficienciesThe DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombinationConditional RAG-1 mutants block the hairpin formation step of V(D)J recombination.A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.Rag-1 mutations associated with B-cell-negative scid dissociate the nicking and transesterification steps of V(D)J recombination.Functional organization of single and paired V(D)J cleavage complexesRAG transposase can capture and commit to target DNA before or after donor cleavage
P2860
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P2860
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
description
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
im Dezember 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/12/01)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/12/01)
@nl
наукова стаття, опублікована в грудні 1999
@uk
научни чланак (објављен 1999/12/01)
@sr
name
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
@ast
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
@en
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
@nl
type
label
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
@ast
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
@en
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
@nl
prefLabel
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
@ast
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
@en
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
@nl
P2093
P2860
P356
P1433
P1476
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
@en
P2093
P2860
P304
P356
10.1101/GAD.13.23.3070
P577
1999-12-01T00:00:00Z