Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity
about
Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XLProtection from rapamycin-induced apoptosis by insulin-like growth factor-I is partially dependent on protein kinase C signalingInduction of apoptosis by p110C requires mitochondrial translocation of the proapoptotic BCL-2 family member BADA novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasisProtein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosisIdentification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylationBAD: a good therapeutic target?Tuning a Three-Component Reaction For Trapping Kinase Substrate ComplexesThe proapoptotic BH3-only protein BAD transduces cell death signals independently of its interaction with Bcl-2Intrinsically disordered proteins in bcl-2 regulated apoptosis.Mesenchymal stem cells secrete multiple cytokines that promote angiogenesis and have contrasting effects on chemotaxis and apoptosis.A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic responseActivating Akt and the brain's resources to drive cellular survival and prevent inflammatory injuryErythropoietin on a tightrope: balancing neuronal and vascular protection between intrinsic and extrinsic pathways.Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better?BCL2 family of apoptosis-related genes: functions and clinical implications in cancer.Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure.The Impact of Reproductive Technologies on Stallion Mitochondrial Function.CaMKII-γ mediates phosphorylation of BAD at Ser170 to regulate cytokine-dependent survival and proliferation.Methylseleninic acid sensitizes prostate cancer cells to TRAIL-mediated apoptosis.A proteolytic fragment of Mcl-1 exhibits nuclear localization and regulates cell growth by interaction with Cdk1.Mutation of BAD within the BH3 domain impairs its phosphorylation-mediated regulation.BAD contributes to RAF-mediated proliferation and cooperates with B-RAF-V600E in cancer signaling.CaMKII and CaMKIV mediate distinct prosurvival signaling pathways in response to depolarization in neurons.Calcineurin-mediated Bad translocation regulates cyanide-induced neuronal apoptosis.Cytokine-stimulated phosphorylation of GSK-3 is primarily dependent upon PKCs, not PKB.
P2860
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P2860
Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity
description
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2002
@ast
im Februar 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/02/22)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/02/22)
@nl
наукова стаття, опублікована в лютому 2002
@uk
name
Identification of a novel phos ...... of bad pro-apoptotic activity
@ast
Identification of a novel phos ...... of bad pro-apoptotic activity
@en
Identification of a novel phos ...... of bad pro-apoptotic activity
@nl
type
label
Identification of a novel phos ...... of bad pro-apoptotic activity
@ast
Identification of a novel phos ...... of bad pro-apoptotic activity
@en
Identification of a novel phos ...... of bad pro-apoptotic activity
@nl
prefLabel
Identification of a novel phos ...... of bad pro-apoptotic activity
@ast
Identification of a novel phos ...... of bad pro-apoptotic activity
@en
Identification of a novel phos ...... of bad pro-apoptotic activity
@nl
P2093
P2860
P921
P356
P1476
Identification of a novel phos ...... of bad pro-apoptotic activity
@en
P2093
Arpita Maiti
Kathryn Schubert
Michael P. Scheid
Payman Hojabrpour
Shaynoor Dramsi
Vincent Duronio
Xianming Chen
P2860
P304
P356
10.1074/JBC.M109990200
P407
P577
2002-02-22T00:00:00Z