Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons
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Characterization of cognitive deficits in rats overexpressing human alpha-synuclein in the ventral tegmental area and medial septum using recombinant adeno-associated viral vectorsK-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration.Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous systemPresynaptic dopaminergic compartment determines the susceptibility to L-DOPA-induced dyskinesia in ratsPuromycin-resistant lentiviral control shRNA vector, pLKO.1 induces unexpected cellular differentiation of P19 embryonic stem cells.Gene delivery with viral vectors for cerebrovascular diseases.α-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration.Differential distribution of heparan sulfate glycoforms and elevated expression of heparan sulfate biosynthetic enzyme genes in the brain of mucopolysaccharidosis IIIB mice.A microRNA embedded AAV α-synuclein gene silencing vector for dopaminergic neurons.Distinct cognitive effects and underlying transcriptome changes upon inhibition of individual miRNAs in hippocampal neurons.Viral delivery of shRNA to amygdala neurons leads to neurotoxicity and deficits in Pavlovian fear conditioningDesign of a single AAV vector for coexpression of TH and GCH1 to establish continuous DOPA synthesis in a rat model of Parkinson's diseaseHypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.Toxic effects of human and rodent variants of alpha-synuclein in vivo.Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1(G93A) Mice and Nonhuman Primates.Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.Studies of efficacy and liver toxicity related to adeno-associated virus-mediated RNA interference.Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines.Knockdown of tyrosine hydroxylase in the nucleus of the solitary tract reduces elevated blood pressure during chronic intermittent hypoxia.Recombinant AAV as a platform for translating the therapeutic potential of RNA interference.Lentiviral vector-mediated RNA silencing in the central nervous system.Lentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in central nervous system neurones.Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: positive and negative effects.AAV: An Overview of Unanswered Questions.Knockdown of GAD67 protein levels normalizes neuronal activity in a rat model of Parkinson's disease.The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression.Identification of the miRNA targetome in hippocampal neurons using RIP-seq.shRNA-induced saturation of the microRNA pathway in the rat brain.GHS-R1a signaling in the DMH and VMH contributes to food anticipatory activity.In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degenerationCharacterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors.Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration.
P2860
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P2860
Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Dose optimization for long-ter ...... grostriatal projection neurons
@ast
Dose optimization for long-ter ...... grostriatal projection neurons
@en
Dose optimization for long-ter ...... grostriatal projection neurons
@nl
type
label
Dose optimization for long-ter ...... grostriatal projection neurons
@ast
Dose optimization for long-ter ...... grostriatal projection neurons
@en
Dose optimization for long-ter ...... grostriatal projection neurons
@nl
prefLabel
Dose optimization for long-ter ...... grostriatal projection neurons
@ast
Dose optimization for long-ter ...... grostriatal projection neurons
@en
Dose optimization for long-ter ...... grostriatal projection neurons
@nl
P2093
P2860
P356
P1433
P1476
Dose optimization for long-ter ...... grostriatal projection neurons
@en
P2093
Ayse Ulusoy
Deniz Kirik
Gurdal Sahin
Patrick Aebischer
Tomas Björklund
P2860
P304
P356
10.1038/MT.2009.142
P577
2009-07-07T00:00:00Z