The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy
about
Targeting protein-protein interactions in complexes organized by A kinase anchoring proteinsAKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophyA-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in α1-adrenergic receptor-induced p38 activationThe crystal structure of the RhoA-AKAP-Lbc DH-PH domain complexA-kinase-anchoring protein-Lbc anchors IκB kinase β to support interleukin-6-mediated cardiomyocyte hypertrophyPeripheral and central effects of circulating catecholaminesNetworking with AKAPs: context-dependent regulation of anchored enzymesAn adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytesA-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophyThe Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in miceAKAP-Lbc mobilizes a cardiac hypertrophy signaling pathwayDisruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function.Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.The Lbc Rho guanine nucleotide exchange factor α-catulin axis functions in serotonin-induced vascular smooth muscle cell mitogenesis and RhoA/ROCK activation.Chromodomain helicase binding protein 8 (Chd8) is a novel A-kinase anchoring protein expressed during rat cardiac development.The α1-adrenergic receptors: diversity of signaling networks and regulationAnchored protein kinase A recruitment of active Rac GTPase.AKAPs: the architectural underpinnings of local cAMP signaling.A-kinase anchoring proteins: scaffolding proteins in the heart.Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand SpecificityRhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response.A-kinase anchoring proteins as potential drug targets.Scaffolding proteins in G-protein signalingThe A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16).Src homology 2 domain-containing phosphatase 2 (Shp2) is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex and is inhibited by protein kinase A (PKA) under pathological hypertrophic conditions in the heartAnchoring proteins as regulators of signaling pathways.Acute β-adrenergic activation triggers nuclear import of histone deacetylase 5 and delays G(q)-induced transcriptional activationCreating order from chaos: cellular regulation by kinase anchoring.Signalosomes as Therapeutic Targets.AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction.A-kinase anchoring proteins: from protein complexes to physiology and diseaseAKAP-scaffolding proteins and regulation of cardiac physiology.The ubiquitin-like protein LC3 regulates the Rho-GEF activity of AKAP-LbcSignal integration through blending, bolstering and bifurcating of intracellular information.Revisited and revised: is RhoA always a villain in cardiac pathophysiology?Cardiac and neuroprotection regulated by α(1)-adrenergic receptor subtypesG protein-dependent and G protein-independent signaling pathways and their impact on cardiac function.A-kinase anchoring proteins that regulate cardiac remodeling.Promotion and inhibition of cardiac hypertrophy by A-kinase anchor proteins.
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P2860
The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy
description
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2007
@ast
im Juni 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/06/12)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/06/12)
@nl
наукова стаття, опублікована в червні 2007
@uk
name
The A-kinase anchoring protein ...... uced cardiomyocyte hypertrophy
@ast
The A-kinase anchoring protein ...... uced cardiomyocyte hypertrophy
@en
The A-kinase anchoring protein ...... uced cardiomyocyte hypertrophy
@nl
type
label
The A-kinase anchoring protein ...... uced cardiomyocyte hypertrophy
@ast
The A-kinase anchoring protein ...... uced cardiomyocyte hypertrophy
@en
The A-kinase anchoring protein ...... uced cardiomyocyte hypertrophy
@nl
prefLabel
The A-kinase anchoring protein ...... uced cardiomyocyte hypertrophy
@ast
The A-kinase anchoring protein ...... uced cardiomyocyte hypertrophy
@en
The A-kinase anchoring protein ...... uced cardiomyocyte hypertrophy
@nl
P2093
P2860
P356
P1476
The A-kinase anchoring protein ...... uced cardiomyocyte hypertrophy
@en
P2093
Aline Appert-Collin
Dario Diviani
Monique Nenniger-Tosato
Susanna Cotecchia
P2860
P304
10140–10145
P356
10.1073/PNAS.0701099104
P407
P577
2007-06-12T00:00:00Z