Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments
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Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis.Localization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestineThe Niemann-Pick C1 and caveolin-1 proteins interact to modulate efflux of low density lipoprotein-derived cholesterol from late endocytic compartments.A novel mouse model of Niemann-Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations.Real-time gene delivery vector tracking in the endo-lysosomal pathway of live cellsThe National Niemann-Pick Type C1 Disease Database: correlation of lipid profiles, mutations, and biochemical phenotypes.Analysis of Lujo virus cell entry using pseudotype vesicular stomatitis virus.A marked paucity of granule cells in the developing cerebellum of the Npc1(-/-) mouse is corrected by a single injection of hydroxypropyl-β-cyclodextrinNpc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance.NPC1 in human white adipose tissue and obesity.Mutations of a Drosophila NPC1 gene confer sterol and ecdysone metabolic defectsNpc1 acting in neurons and glia is essential for the formation and maintenance of CNS myelin.Decreased Npc1 gene dosage in mice is associated with weight gain.A cholesterol-regulated PP2A/HePTP complex with dual specificity ERK1/2 phosphatase activity.Gene-diet interactions in childhood obesity.Genetic variation in the mouse model of Niemann Pick C1 affects female, as well as male, adiposity, and hepatic bile transporters but has indeterminate effects on caveolaeDifferential Association of Niemann-Pick C1 Gene Polymorphisms with Maternal Prepregnancy Overweight and Gestational Diabetes.Neuronal loss of Drosophila NPC1a causes cholesterol aggregation and age-progressive neurodegeneration.Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblastsA caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance.The Niemann-Pick C1 gene is downregulated in livers of C57BL/6J mice by dietary fatty acids, but not dietary cholesterol, through feedback inhibition of the SREBP pathway.The Niemann-Pick C1 gene is downregulated by feedback inhibition of the SREBP pathway in human fibroblasts.Subversion of NPC1 pathway of cholesterol transport by Anaplasma phagocytophilum.Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complexAmelioration of muscular dystrophy by transgenic expression of Niemann-Pick C1.Niemann-Pick C2 (NPC2) and intracellular cholesterol trafficking.The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways.Pulmonary function and pathology in hydroxypropyl-beta-cyclodextin-treated and untreated Npc1⁻/⁻ mice.Tau normal function influences Niemann-Pick type C disease pathogenesis in mice and modulates autophagy in NPC1-deficient cells.Gene-nutrient interactions and susceptibility to human obesity.
P2860
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P248
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P2860
Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments
description
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Mai 2000 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2000/05/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/05/01)
@nl
наукова стаття, опублікована в травні 2000
@uk
مقالة علمية (نشرت في مايو 2000)
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name
Localization of the murine Nie ...... nct intracellular compartments
@ast
Localization of the murine Nie ...... nct intracellular compartments
@en
Localization of the murine Nie ...... nct intracellular compartments
@nl
type
label
Localization of the murine Nie ...... nct intracellular compartments
@ast
Localization of the murine Nie ...... nct intracellular compartments
@en
Localization of the murine Nie ...... nct intracellular compartments
@nl
prefLabel
Localization of the murine Nie ...... nct intracellular compartments
@ast
Localization of the murine Nie ...... nct intracellular compartments
@en
Localization of the murine Nie ...... nct intracellular compartments
@nl
P2093
P921
P1476
Localization of the murine Nie ...... nct intracellular compartments
@en
P2093
J. M. Wilson
M. A. Thomas
R. A. Heidenreich
R. P. Erickson
W. S. Garver
P304
P577
2000-05-01T00:00:00Z