Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
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NK Cell and CD4+FoxP3+ Regulatory T Cell Based Therapies for Hematopoietic Stem Cell EngraftmentBeyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint RegulatorsTIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV InfectionStructure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clusteringProspects of immune checkpoint modulators in the treatment of glioblastomaTIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy.DNAM-1 control of natural killer cells functions through nectin and nectin-like proteins.Identification of CD112R as a novel checkpoint for human T cells.Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets.T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signalingTreg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responsesTranscriptional profile of tuberculosis antigen-specific T cells reveals novel multifunctional featuresTIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients.Agonistic anti-TIGIT treatment inhibits T cell responses in LDLr deficient mice without affecting atherosclerotic lesion developmentCell surface signaling molecules in the control of immune responses: a tide model.Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.The TIGIT/CD226 axis regulates human T cell functionHTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT).The Role of T Cell Costimulation via DNAM-1 in Kidney Transplantation.Inhibitory receptors as targets for cancer immunotherapyDendritic cell immunotherapy versus bevacizumab plus irinotecan in recurrent malignant glioma patients: a survival gain analysis.A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosisTIGIT predominantly regulates the immune response via regulatory T cells.T-cell exhaustion in the tumor microenvironment.Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells.TIGIT-positive circulating follicular helper T cells display robust B-cell help functions: potential role in sickle cell alloimmunization.CD4+ and CD8+ T Cell Activation in Children with Hepatitis C.Costimulatory and Coinhibitory Receptor Pathways in Infectious DiseaseCo-stimulatory and Co-inhibitory Pathways in Autoimmunity.CD226 ligation protects against EAE by promoting IL-10 expression via regulation of CD4+ T cell differentiation.Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection.Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cellsRecent advances and future of immunotherapy for glioblastoma.Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease.The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans.Impact of the gut microbiota on enhancer accessibility in gut intraepithelial lymphocytes.Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals.The DC-HIL/syndecan-4 pathway regulates autoimmune responses through myeloid-derived suppressor cells.Expression of immune checkpoints in T cells of esophageal cancer patientsElevated expression of TIGIT on CD3+CD4+ T cells correlates with disease activity in systemic lupus erythematosus.
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Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
description
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
@ast
im Februar 2011 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2011/02/01)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/02/01)
@nl
наукова стаття, опублікована в лютому 2011
@uk
مقالة علمية (نشرت في فبراير 2011)
@ar
name
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
@ast
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
@en
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
@nl
type
label
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
@ast
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
@en
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
@nl
prefLabel
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
@ast
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
@en
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
@nl
P2093
P2860
P3181
P356
P1476
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
@en
P2093
Arlene H Sharpe
Boel Brynedal
Jason P Hafler
Nasim Kassam
Silvia Spoerl
Steven D Levin
Vijay K Kuchroo
P2860
P304
P3181
P356
10.4049/JIMMUNOL.1003081
P407
P577
2011-01-03T00:00:00Z