T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signaling

T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signaling

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http://www.wikidata.org/entity/Q33792958

Q33792958

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Natural Killer Cell Recognition of Melanoma: New Clues for a More Effective Immunotherapy Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators Multifaceted role of β-arrestins in inflammation and disease TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy.Balancing natural killer cell activation through paired receptors.TIGIT predominantly regulates the immune response via regulatory T cells.Elevated expression of TIGIT on CD3+CD4+ T cells correlates with disease activity in systemic lupus erythematosus.Altered expression of CD226 and CD96 on natural killer cells in patients with pancreatic cancer Elevated Expression of Immunoreceptor Tyrosine-Based Inhibitory Motif (TIGIT) on T Lymphocytes is Correlated with Disease Activity in Rheumatoid Arthritis.Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy.Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy.Immunoreceptor TIGIT inhibits the cytotoxicity of human cytokine-induced killer cells by interacting with CD155.Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.Immune checkpoint inhibitors for cancer treatment.TIGIT, A Novel Therapeutic Target for Tumor Immunotherapy.T cell exhaustion: from pathophysiological basics to tumor immunotherapy.Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma.NK Cell Exhaustion.CD155, an onco-immunologic molecule in human tumors.Poliovirus Receptor: More than a simple viral receptor.TIGIT expression levels on human NK cells correlate with functional heterogeneity among healthy individuals.The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8(+) T cell responses.The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer.TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia.T cells expressing checkpoint receptor TIGIT are enriched in follicular lymphoma tumors and characterized by reversible suppression of T-cell receptor signaling.Mining the Complex Family of Protein Tyrosine Phosphatases for Checkpoint Regulators in Immunity.Checkpoint Inhibitors: Applications for Autoimmunity.Tim-3, Lag-3, and TIGIT.Targeting Checkpoint Receptors and Molecules for Therapeutic Modulation of Natural Killer Cells Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer Immune checkpoints PVR and PVRL2 are prognostic markers in AML and their blockade represents a new therapeutic option Expression of the Inhibitory Receptor TIGIT Is Up-Regulated Specifically on NK Cells With CD226 Activating Receptor From HIV-Infected Individuals Combinational immune-cell therapy of natural killer cells and sorafenib for advanced hepatocellular carcinoma: a review

P2860

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P2860

T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signaling

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http://www.wikidata.org/entity/Q33792958

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