The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds - Wikidata - thesis-toulmin - TriplyDB

The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

http://www.wikidata.org/entity/Q28755952

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Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2 Role of Nrf2 in oxidative stress and toxicity Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2 NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level Cysteine-based regulation of the CUL3 adaptor protein Keap1 NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer Redox signaling regulated by electrophiles and reactive sulfur species The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damage Redox control of microglial function: molecular mechanisms and functional significance Hydrogen peroxide sensing, signaling and regulation of transcription factors Roles nrf2 plays in myeloid cells and related disorders Embryonic oxidative stress results in reproductive impairment for adult zebrafish.Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO Nrf2 mediates redox adaptations to exercise TrxR1 as a potent regulator of the Nrf2-Keap1 response system Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents Exploiting dependencies of pairwise comparison outcomes to predict patterns of gene response CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2 Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids Sulforaphane protects the heart from doxorubicin-induced toxicity The electrophile responsive proteome: integrating proteomics and lipidomics with cellular function The complexity of the Nrf2 pathway: beyond the antioxidant response Generation and biological activities of oxidized phospholipids Basic principles and emerging concepts in the redox control of transcription factors Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin Dual NRF2 paralogs in Coho salmon and their antioxidant response element targets Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish In Situ Observation of Thiol Michael Addition to a Reversible Covalent Drug in a Crystalline Sponge.Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes.

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The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

http://www.wikidata.org/entity/Q28755952

description

2009 nî lūn-bûn

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2009 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2009 թվականի հունվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

The antioxidant defense system ...... de range of chemical compounds

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The antioxidant defense system ...... de range of chemical compounds

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Molecular and Cellular Biology

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The antioxidant defense system ...... de range of chemical compounds

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Hiroshi Kaneko

http://www.w3.org/2001/XMLSchema#string

Li Li

http://www.w3.org/2001/XMLSchema#string

Makoto Kobayashi

http://www.w3.org/2001/XMLSchema#string

Masami Eguchi

http://www.w3.org/2001/XMLSchema#string

Masayuki Yamamoto

http://www.w3.org/2001/XMLSchema#string

Noriko Iwamoto

http://www.w3.org/2001/XMLSchema#string

Yaeko Nakajima-Takagi

http://www.w3.org/2001/XMLSchema#string

Yoshiko Wada

http://www.w3.org/2001/XMLSchema#string

Yoshito Kumagai

http://www.w3.org/2001/XMLSchema#string

Yuko Nakayama

http://www.w3.org/2001/XMLSchema#string

P2860

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China

Ebselen, a seleno-organic antioxidant, as an electrophile

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

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493-502

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scholarly article

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1105628

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10.1128/MCB.01080-08

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2

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29

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2009-01-01T00:00:00Z

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23465582

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19001094

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2612520

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