Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
about
p53 activation by knockdown technologiesStabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX proteinTurning the RING domain protein MdmX into an active ubiquitin-protein ligaseRegulation of p53 stability and function by the deubiquitinating enzyme USP42Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradationRFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damageUSP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosisNegative regulation of p53 functions by Daxx and the involvement of MDM214-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activationAnti-apoptotic protein TCTP controls the stability of the tumor suppressor p53RYBP stabilizes p53 by modulating MDM2Acetylation is indispensable for p53 activationFBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activityIdentification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domainsProteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradationA novel ARF-binding protein (LZAP) alters ARF regulation of HDM2An essential function of the extreme C-terminus of MDM2 can be provided by MDMXRepression of p53-mediated transcription by MDM2: a dual mechanismMutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stabilityMDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathwayHIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic functionTrim24 targets endogenous p53 for degradationThe Mdm2 oncoprotein interacts with the cell fate regulator NumbTargeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis.MDM2 suppresses p73 function without promoting p73 degradationMDMX: a novel p53-binding protein with some functional properties of MDM2Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibitionVisualization and targeted disruption of protein interactions in living cellsp53-independent functions of the p19(ARF) tumor suppressorA TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback controlNedd4 controls animal growth by regulating IGF-1 signalingThe first 30 years of p53: growing ever more complexRibosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathwaySmall-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapyThe alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradationInduction of cullin 7 by DNA damage attenuates p53 function
P2860
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P2860
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
description
1995 nî lūn-bûn
@nan
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
@ast
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
@en
type
label
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
@ast
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
@en
prefLabel
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
@ast
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
@en
P2093
P3181
P356
P1433
P1476
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
@en
P2093
P2888
P3181
P356
10.1038/378206A0
P407
P577
1995-11-09T00:00:00Z
P6179
1007191650