GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
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A THEMIS:SHP1 complex promotes T-cell survivalEarly Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin NetworkModest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal SignalingGrb2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner.GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.Themis2 is not required for B cell development, activation, and antibody responses.Fine-tuning T cell receptor signaling to control T cell developmentTespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.THEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis.Differential function of Themis CABIT domains during T cell developmentCombinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor.In vivo functional mapping of the conserved protein domains within murine Themis1Increased THEMIS First Exon Usage in CD4+ T-Cells Is Associated with a Genotype that Is Protective against Multiple SclerosisTHEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.Themis sets the signal threshold for positive and negative selection in T-cell developmentThe actin-driven spatiotemporal organization of T-cell signaling at the system scale.Integrative biology of T cell activation.Lighting Up T Lymphocyte Signaling with Quantitative Phosphoproteomics.THEMIS: Two Models, Different Thresholds.Systems Imaging of the Immune Synapse.Generation of Peptides That Promote Positive Selection in the Thymus.Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selectionThemis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.TCR signalling network organization at the immunological synapses of murine regulatory T cells.Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis.Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection.Proteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function.Themis2 lowers the threshold for B cell activation during positive selection.SHP1-ing thymic selection.
P2860
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P2860
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
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2013 թուականի Մարտին հրատարակուած գիտական յօդուած
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2013 թվականի մարտին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
@ast
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
@en
type
label
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
@ast
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
@en
prefLabel
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
@ast
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
@en
P2093
P2860
P3181
P356
P1476
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
@en
P2093
Ana Martinez-Riaño
Ben de Wet
Christoph Wülfing
Claudia Brockmeyer
John A H Hoerter
Oreste Acuto
Philip C Simister
Stephan M Feller
Wolfgang Paster
P2860
P304
P3181
P356
10.4049/JIMMUNOL.1203389
P407
P577
2013-03-04T00:00:00Z