Mapping the conformational transition in Src activation by cumulating the information from multiple molecular dynamics trajectories
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Taming the complexity of protein foldingRevealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics SimulationsDevelopment of a murine model for aerosolized ebolavirus infection using a panel of recombinant inbred miceHotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivityThe Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape.Imatinib binding to human c-Src is coupled to inter-domain allostery and suggests a novel kinase inhibition strategyLocking the active conformation of c-Src kinase through the phosphorylation of the activation loopHierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations.A comparative analysis of clustering algorithms: O2 migration in truncated hemoglobin I from transition networks.Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.The energy landscape analysis of cancer mutations in protein kinasesSequence and structure signatures of cancer mutation hotspots in protein kinasesLarge conformational changes in proteins: signaling and other functions.Relationships between structural dynamics and functional kinetics in oligomeric membrane receptorsThe mechanical properties of PCNA: implications for the loading and function of a DNA sliding clamp.Protein folded states are kinetic hubs.Conformational Transition Pathways of Epidermal Growth Factor Receptor Kinase Domain from Multiple Molecular Dynamics Simulations and Bayesian Clustering.Network models for molecular kinetics and their initial applications to human healthMultidomain assembled states of Hck tyrosine kinase in solution.Maximum Flux Transition Paths of Conformational ChangeEquilibrium fluctuations of a single folded protein reveal a multitude of potential cryptic allosteric sites.Quantitative analysis of ligand migration from transition networksOn the Application of Molecular-Dynamics Based Markov State Models to Functional Proteins.Activation pathway of Src kinase reveals intermediate states as targets for drug designProtein folding is mechanistically robust.Allostery through the computational microscope: cAMP activation of a canonical signalling domain"DFG-flip" in the insulin receptor kinase is facilitated by a helical intermediate state of the activation loop.Molecular Dynamics Simulations and Classical Multidimensional Scaling Unveil New Metastable States in the Conformational Landscape of CDK2.Mapping L1 ligase ribozyme conformational switch.Transitions to catalytically inactive conformations in EGFR kinaseNMR relaxation in proteins with fast internal motions and slow conformational exchange: model-free framework and Markov state simulationsTransition path theory analysis of c-Src kinase activationMolecular modeling of ErbB4/HER4 kinase in the context of the HER4 signaling network helps rationalize the effects of clinically identified HER4 somatic mutations on the cell phenotype.Nucleotide Dependent Switching in Rho GTPase: Conformational Heterogeneity and Competing Molecular Interactions.Modeling conformational transitions in kinases by molecular dynamics simulations: achievements, difficulties, and open challengesTheoretical and computational studies of peptides and receptors of the insulin family.Exploiting computationally derived out-of-the-box protein conformations for drug design.ADAM15 protein amplifies focal adhesion kinase phosphorylation under genotoxic stress conditionsCharacterization and rapid sampling of protein folding Markov state model topologies
P2860
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P2860
Mapping the conformational transition in Src activation by cumulating the information from multiple molecular dynamics trajectories
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Mapping the conformational tra ...... olecular dynamics trajectories
@ast
Mapping the conformational tra ...... olecular dynamics trajectories
@en
type
label
Mapping the conformational tra ...... olecular dynamics trajectories
@ast
Mapping the conformational tra ...... olecular dynamics trajectories
@en
prefLabel
Mapping the conformational tra ...... olecular dynamics trajectories
@ast
Mapping the conformational tra ...... olecular dynamics trajectories
@en
P2860
P356
P1476
Mapping the conformational tra ...... olecular dynamics trajectories
@en
P2093
Benoît Roux
P2860
P304
P356
10.1073/PNAS.0808261106
P407
P577
2009-02-18T00:00:00Z