The APC/C inhibitor, Emi1, is essential for prevention of rereplication
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The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombinationThe RASSF1A tumor suppressor restrains anaphase-promoting complex/cyclosome activity during the G1/S phase transition to promote cell cycle progression in human epithelial cellsReplication licensing and cancer--a fatal entanglement?Selective killing of cancer cells by suppression of geminin activityThe anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cyclesMechanisms to control rereplication and implications for cancer.The Non-Canonical Role of Aurora-A in DNA ReplicationThe Evi5 family in cellular physiology and pathologyGenomic instability in cancer.Modulation of cell cycle control during oocyte-to-embryo transitionsHypersensitivity to DNA damage in antephase as a safeguard for genome stability.The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylationQuaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensingElectron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdownPseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation.Replication fork instability and the consequences of fork collisions from rereplicationSpatiotemporal regulation of the anaphase-promoting complex in mitosisIdentification of genes that are essential to restrict genome duplication to once per cell divisionInactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma.The HBx oncoprotein of hepatitis B virus deregulates the cell cycle by promoting the intracellular accumulation and re-compartmentalization of the cellular deubiquitinase USP37.Cyclin A degradation by primate cytomegalovirus protein pUL21a counters its innate restriction of virus replication.Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.Inhibition of human cytomegalovirus immediate-early gene expression by cyclin A2-dependent kinase activityAPC/C--the master controller of origin licensing?Checkpoint effects and telomere amplification during DNA re-replication in fission yeast.Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome.Centriole reduplication during prolonged interphase requires procentriole maturation governed by Plk1.The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.High-throughput screening for genes that prevent excess DNA replication in human cells and for molecules that inhibit themTension and robustness in multitasking cellular networks.Impact of α-targeted radiation therapy on gene expression in a pre-clinical model for disseminated peritoneal disease when combined with paclitaxel.Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.Replication licensing and the DNA damage checkpoint.Life without geminin.Characterization of harpy/Rca1/emi1 mutants: patterning in the absence of cell division.Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplicationDeregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template.Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancerSP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition.MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C.
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P2860
The APC/C inhibitor, Emi1, is essential for prevention of rereplication
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The APC/C inhibitor, Emi1, is essential for prevention of rereplication
@ast
The APC/C inhibitor, Emi1, is essential for prevention of rereplication
@en
type
label
The APC/C inhibitor, Emi1, is essential for prevention of rereplication
@ast
The APC/C inhibitor, Emi1, is essential for prevention of rereplication
@en
prefLabel
The APC/C inhibitor, Emi1, is essential for prevention of rereplication
@ast
The APC/C inhibitor, Emi1, is essential for prevention of rereplication
@en
P2860
P921
P356
P1433
P1476
The APC/C inhibitor, Emi1, is essential for prevention of rereplication
@en
P2093
Yuichi J Machida
P2860
P304
P356
10.1101/GAD.1495007
P577
2007-01-01T00:00:00Z