Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication
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The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaksDVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocksRing of Change: CDC48/p97 Drives Protein Dynamics at ChromatinThe p97 ATPase associates with EEA1 to regulate the size of early endosomesCovalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell deathThe ERAD inhibitor Eeyarestatin I is a bifunctional compound with a membrane-binding domain and a p97/VCP inhibitory groupA non-canonical role of the p97 complex in RIG-I antiviral signalingThe UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replicationRNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegansThe CRL2LRR-1 ubiquitin ligase regulates cell cycle progression during C. elegans development.Autophagy protects C. elegans against necrosis during Pseudomonas aeruginosa infection.The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.TIGAR induces p53-mediated cell-cycle arrest by regulation of RB-E2F1 complexA screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans.Concerted action of the ubiquitin-fusion degradation protein 1 (Ufd1) and Sumo-targeted ubiquitin ligases (STUbLs) in the DNA-damage response.Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy.Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopyCoordinate to guard: crosstalk of phosphorylation, sumoylation, and ubiquitylation in DNA damage response.CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.Revoking the cellular license to replicate: yet another AAA assignment.Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome.Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.Role of p97/VCP (Cdc48) in genome stability.Single base substitution in OsCDC48 is responsible for premature senescence and death phenotype in rice.Decoding ubiquitin for mitosis.The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation.Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication.On-site remodeling at chromatin: How multiprotein complexes are rebuilt during DNA repair and transcriptional activation.Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction.Termination of DNA replication forks: "Breaking up is hard to do".Proteome Stability as a Key Factor of Genome Integrity.The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis
P2860
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P2860
Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Cell cycle progression require ...... for efficient DNA replication
@ast
Cell cycle progression require ...... for efficient DNA replication
@en
type
label
Cell cycle progression require ...... for efficient DNA replication
@ast
Cell cycle progression require ...... for efficient DNA replication
@en
prefLabel
Cell cycle progression require ...... for efficient DNA replication
@ast
Cell cycle progression require ...... for efficient DNA replication
@en
P2093
P2860
P50
P356
P1476
Cell cycle progression require ...... for efficient DNA replication
@en
P2093
Alexandra Deichsel
Carsten Hoege
Julien Mouysset
Sandra Moser
P2860
P304
12879-12884
P356
10.1073/PNAS.0805944105
P407
P577
2008-08-26T00:00:00Z