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The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaksRing of Change: CDC48/p97 Drives Protein Dynamics at ChromatinCreate and preserve: proteostasis in development and aging is governed by Cdc48/p97/VCPThe Myosin Chaperone UNC-45 Is Organized in Tandem Modules to Support Myofilament Formation in C. elegansMobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone.The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B.A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replicationRole of sirtuins in lifespan regulation is linked to methylation of nicotinamide.The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor TurnoverActivation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivoMembrane-bound transcription factors: regulated release by RIP or RUP.Life and destruction: ubiquitin-mediated proteolysis in aging and longevityA screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans.Regulation of the DNA damage response by ubiquitin conjugation.Challenging muscle homeostasis uncovers novel chaperone interactions in Caenorhabditis elegansMultiubiquitylation by E4 enzymes: 'one size' doesn't fit all.The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegansCDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome.Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.Protein quality control gets muscle into shape.Think locally: control of ubiquitin-dependent protein degradation in neuronsThe ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication.E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosisGrowing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin.Ubiquitin sets the timer: impacts on aging and longevity.MicroRNAs meet calcium: joint venture in ER proteostasis.Double-edged alliance: mitochondrial surveillance by the UPS and autophagy.Reversible 26S proteasome disassembly upon mitochondrial stress.Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system.Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA.Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasisAnalysis of ubiquitin-dependent proteolysis in Caenorhabditis elegans.The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy.Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity.A novel interaction between aging and ER overload in a protein conformational dementia.Erratum: Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin.
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description
hulumtues
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հետազոտող
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Thorsten Hoppe
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Thorsten Hoppe
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Thorsten Hoppe
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Thorsten Hoppe
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P1153
7004589561
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P31
P496
0000-0002-4734-9352