Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly - Wikidata - thesis-toulmin - TriplyDB

Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly

Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly

http://www.wikidata.org/entity/Q30490856

about

Neuronal migration and its disorders affecting the CA3 region mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1 Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly.The genetics of lissencephaly.Differential Mitochondrial Requirements for Radially and Non-radially Migrating Cortical Neurons: Implications for Mitochondrial Disorders.Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense.The exon junction complex component Magoh controls brain size by regulating neural stem cell division.Calpain chronicle--an enzyme family under multidisciplinary characterization Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival.Regulation and physiological roles of the calpain system in muscular disorders ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice Early rescue of interneuron disease trajectory in developmental epilepsies.Lissencephaly: mechanistic insights from animal models and potential therapeutic strategies.Impact of genetic insights into calpain biology.Ndel1, Nudel (Noodle): flexible in the cell?DISC1 Pathway in Brain Development: Exploring Therapeutic Targets for Major Psychiatric Disorders.LIS1 and DCX: Implications for Brain Development and Human Disease in Relation to Microtubules.Introduction: Brain malformations.Calpain research for drug discovery: challenges and potential.Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning Potential Role of Microtubule Stabilizing Agents in Neurodevelopmental Disorders.Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein.A novel strategy for therapeutic intervention for the genetic disease: preventing proteolytic cleavage using small chemical compound.The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogensis.Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement.An anti-CAPN5 intracellular antibody acts as an inhibitor of CAPN5-mediated neuronal degeneration.Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport.A Gastrointestinal Calpain Complex, G-calpain, Is a Heterodimer of CAPN8 and CAPN9 Calpain Isoforms, Which Play Catalytic and Regulatory Roles, Respectively.Tubacin prevents neuronal migration defects and epileptic activity caused by rat Srpx2 silencing in utero.Efficient expression and purification of recombinant human μ-calpain using an Escherichia coli expression system.Neurodevelopmental Genetic Diseases Associated With Microdeletions and Microduplications of Chromosome 17p13.3.In Utero Administration of Drugs Targeting Microglia Improves the Neurodevelopmental Outcome Following Cytomegalovirus Infection of the Rat Fetal Brain.Hepatic loss of Lissencephaly 1 (Lis1) induces fatty liver and accelerates liver tumorigenesis in mice.In Utero Administration of Drugs Targeting Microglia Improves the Neurodevelopmental Outcome Following Cytomegalovirus Infection of the Rat Fetal Brain.

P2860

Q27024970-70BE6ECA-3D78-4B74-911A-A2861FEF4C59 Q28504660-381EDAD9-C431-4593-BEC6-F5C14D7759EA Q30534573-95FE7F0D-C589-48C6-A136-31E71F5D0E98 Q30826834-6F0FC8A0-2322-4641-94A4-BBEB2505F9E4 Q33625652-3D567C5D-5118-4AB6-A4C5-56D10B756ABD Q33649868-03654C7C-8155-4D29-A446-91807A496120 Q33814636-545240AB-88DC-4F52-B371-2BF605D4C850 Q35157505-83D77CB1-1FC9-498F-9476-D2B63837BCE7 Q35273962-8E7CBF6A-CB51-4D14-B943-FBD168337BEC Q36239537-77A5E3F6-D802-48DA-A5C8-2D04F15FC181 Q36534125-A0FC914B-13DB-461A-85D1-84FA1042B6D8 Q36535757-02B51C51-C5E3-48BC-903D-AFB196EAA28B Q37778122-BD4835D0-766C-4BEC-B4B6-5DD18643BDBA Q37879317-5E484D75-41EE-49F2-A357-86982F7FAFBE Q37939016-3AD7BA06-E2A5-4420-9FA1-0882D6F00CBB Q37998459-F3E6344D-07FF-4065-A4C9-B320C838C342 Q38166377-72F8CF6C-83F4-4C21-AF50-4C8D565A9035 Q38213961-E403297D-544B-4E6A-A95B-55296F386189 Q39004902-0CA124D3-F183-4CDF-8E88-14F8C2104E6D Q41336010-D09607A3-2849-41E9-8B99-763DC4187BAF Q41573058-122215E7-AF87-4C71-B08D-8DA346948F3F Q41780599-F040100D-3D64-429E-BF50-537ACB2FE26E Q41814857-81DBDE80-075A-4009-AAE3-2CD6F86540E7 Q41957932-09BFE05F-9704-4046-B207-5310C00E1465 Q45345948-146B0FB8-ADD0-4BF0-8097-D4728AAC3141 Q47136494-A20444B0-9404-464A-A81A-0F4354EAEE9E Q47166653-D8E8E91A-7324-4A17-859B-5E7282C71A6E Q50194234-DCC68B33-F67D-40D8-A1D5-9100A2525258 Q50735365-162C3CAD-6207-458D-97BE-C216E5621280 Q50891679-362105B6-CD8E-420F-9F51-686917713CF2 Q52431395-310ADF0A-F3A3-4496-AFAB-8DE4F8A1E9D4 Q52645969-1F9D79FE-730E-4785-AE9B-B5706E4D1CCC Q52687753-CF4FE0D8-9EB6-4FF6-BA72-AFC17662ECA4 Q55001631-B2AA4E5C-02E5-44A6-A741-5F0FB9C35B01

P2860

Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly

http://www.wikidata.org/entity/Q30490856

description

2009 nî lūn-bûn

@nan

2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Inhibition of calpain increase ...... a mouse model of lissencephaly

@ast

Inhibition of calpain increase ...... a mouse model of lissencephaly

@en

type

label

Inhibition of calpain increase ...... a mouse model of lissencephaly

@ast

Inhibition of calpain increase ...... a mouse model of lissencephaly

@en

prefLabel

Inhibition of calpain increase ...... a mouse model of lissencephaly

@ast

Inhibition of calpain increase ...... a mouse model of lissencephaly

@en

P1433

Q30490856-61FC09D2-FD3D-4234-A97A-2D6A86BE2DB2

P1476

Q30490856-DF9376F1-8CC7-42AB-8EAE-8796292B7AEE

P2093

Q30490856-01FD2F5B-B382-416C-B8C0-CE334A952C20

Q30490856-13817E13-3FFE-45A1-9498-3A4CB02A6A5D

Q30490856-1A6A5B05-9759-4E80-B598-AA1097CF5AE4

Q30490856-6B8B80BD-3662-428F-B3E0-9F8E67390B72

Q30490856-818ACE36-09A5-4F21-B1E3-093981B16055

Q30490856-91DC6425-A3CE-42DF-AA0F-B8D4065C2057

Q30490856-DF830A88-5725-4BF0-A6FE-EB0A86DB04BB

P2860

Q30490856-02DEDDAD-63CE-483B-92DF-3968C5BE9D00

Q30490856-05E36C83-F966-4B9F-BB32-D78F31C742BC

Q30490856-082804FD-C39E-4306-9B83-8D80F4F59861

Q30490856-1019F8C7-C484-4E7B-81AB-9A00CE866BEC

Q30490856-1165D7CA-DF33-4E77-B68D-1F0FDC80BAED

Q30490856-11AC964B-AB94-4DEE-A41E-0EA757A6C11D

Q30490856-2112444E-679E-4119-9E87-C61125D264B6

Q30490856-291F9457-8CF5-4595-A341-21E963EE1A08

Q30490856-298A0B76-CBBE-4B78-A1D6-12ECCAB71496

Q30490856-2CA14CC8-ED15-4AF3-BA2E-BECAA68A8AB8

P2888

Q30490856-DFDF3475-BF61-4DA0-BC61-E24B55D29AA5

P304

Q30490856-62B4D2DD-A152-4B85-BB47-8D9688399B93

P31

Q30490856-6CE47831-F60E-4274-B6DA-6264BB4BA9BE

P356

Q30490856-3EA699D0-6088-4035-8589-EEB0D5ACD090

P407

Q30490856-A9C1F863-E34D-4BCD-B290-9CFB0BB7517D

P433

Q30490856-C8E7EA70-9ED2-4006-B423-B5A3E5472596

P478

Q30490856-F006B0E8-9D44-4510-804B-CC81CEA700D0

P50

Q30490856-0DD3D5E9-7FFB-4F5D-9BE3-DDF219B9311C

Q30490856-110EB037-C36F-41ED-9B44-04C7954B7328

Q30490856-4434FE41-9E21-4AB9-AC15-8E30A2ED1F33

Q30490856-4C1A6AEC-C516-45B5-B48D-35767C9FB1C7

Q30490856-BFE844FD-D378-4A7B-8E60-945B0A83480D

P577

Q30490856-BCAC80F2-80BE-45C7-82A1-DF8C6346951B

P5875

Q30490856-68775CF9-DA5B-4603-BC37-BD59D65B277B

P6179

Q30490856-0AD7229B-0EFC-49D8-8559-5A66B8F5228E

P698

Q30490856-7F16FF67-4698-4245-AF1E-CF4E1A31E44E

P921

Q30490856-65F52221-9B24-479D-9364-AB9CB3EB6CC4

P932

Q30490856-8E6E7875-F378-453F-8B96-E340F8F530D6

P356

P1433

Nature Medicine

P1476

Inhibition of calpain increase ...... a mouse model of lissencephaly

@en

P2093

Anthony Wynshaw-Boris

http://www.w3.org/2001/XMLSchema#string

Makoto Sato

http://www.w3.org/2001/XMLSchema#string

Masami Yamada

http://www.w3.org/2001/XMLSchema#string

Mineko Kengaku

http://www.w3.org/2001/XMLSchema#string

Shinji Hirotsune

http://www.w3.org/2001/XMLSchema#string

Takako Takitoh

http://www.w3.org/2001/XMLSchema#string

Yuko Yoshida

http://www.w3.org/2001/XMLSchema#string

P2860

Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected]

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

Gait dynamics in mouse models of Parkinson's disease and Huntington's disease.

Neurotoxicity induces cleavage of p35 to p25 by calpain

The calpain system

Biochemical signals and biological responses elicited by the focal adhesion kinase

Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29

Structure, activation, and biology of calpain

Lissencephaly and LIS1: insights into the molecular mechanisms of neuronal migration and development

Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats

P2888

P304

1202-1207

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NM.2023

http://www.w3.org/2001/XMLSchema#string

P407

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

15

http://www.w3.org/2001/XMLSchema#string

P50

Tsuyoshi Miyakawa

Hiroyuki Sorimachi

Hiroki Umeshima

P577

2009-09-06T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

26793934

http://www.w3.org/2001/XMLSchema#string

P6179

1020681723

http://www.w3.org/2001/XMLSchema#string

P698

19734909

http://www.w3.org/2001/XMLSchema#string

P921

P932

2759411

http://www.w3.org/2001/XMLSchema#string