about
The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrityIdentification of muscle specific ring finger proteins as potential regulators of the titin kinase domainInvolvement of calpain-7 in epidermal growth factor receptor degradation via the endosomal sorting pathwayFunctional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2AAn eccentric calpain, CAPN3/p94/calpain-3The protease activity of a calpain-like cysteine protease in Saccharomyces cerevisiae is required for alkaline adaptation and sporulation.The structure of calcium-free human m-calpain: implications for calcium activation and functionCalpain: novel family members, activation, and physiologic functionCalpain-6 deficiency promotes skeletal muscle development and regenerationInduction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signalingInhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephalyThe structure of calpain.Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain.Single-cell chemical lysis method for analyses of intracellular molecules using an array of picoliter-scale microwells.Calpain cleavage prediction using multiple kernel learning.Stable expression of calpain 3 from a muscle transgene in vivo: immature muscle in transgenic mice suggests a role for calpain 3 in muscle maturation.Functional evolution of duplicated odorant-binding protein genes, Obp57d and Obp57e, in Drosophila.Expression of a novel human myotonin protein kinase (MtPK) cDNA clone which encodes a protein with a thymopoietin-like domain in COS cells.Muscle-specific calpain, p94, interacts with the extreme C-terminal region of connectin, a unique region flanked by two immunoglobulin C2 motifs.Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system.Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.Non-proteolytic functions of calpain-3 in sarcoplasmic reticulum in skeletal muscles.Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation.Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho miceThymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells.Regulation and physiological roles of the calpain system in muscular disordersLoss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/nuclear factor kappaB pathway perturbation in mice.Amino acid sequence alignment of vertebrate CAPN3/calpain-3/p94.Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicingRemoval of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy.Expanding members and roles of the calpain superfamily and their genetically modified animals.Impact of genetic insights into calpain biology.Calpains: an elaborate proteolytic system.Understanding the substrate specificity of conventional calpains.Up-regulation of dystrophin mRNA by exposure to dibutyryl cAMP in the C2C12 muscle cell line.Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP.Proteasome inhibitors induce the association of Alzheimer's amyloid precursor protein with Hsc73.Tissue- and cell type-specific expression of mRNAs for four types of inositol phospholipid-specific phospholipase C.Calpain research for drug discovery: challenges and potential.
P50
Q22008009-81EB7615-7FD3-43A9-9EDC-EEC9C08F89E4Q24290911-77B22BFD-9D3A-40E1-930F-ED76C3C7FD1FQ24299711-E50F135D-1248-4B4D-B167-8137125D88A6Q24310208-00913260-DC09-4F18-9AB6-E0AAD33969F0Q26781368-C430FBDA-75F7-4F00-BA5F-F8F8E1F396A1Q27934081-A0DDF587-653E-45D2-A0BE-06C0A387F082Q28201809-CFBEDC70-8D7D-4018-8847-7E272524F9D8Q28273311-B18E22C9-555B-468E-8D21-B4F526AD618DQ28535028-34428C80-2DDD-4186-AE66-98AD3499B1FAQ28585955-EFBC12AE-CCA5-442D-864E-46CE54E66E09Q30490856-110EB037-C36F-41ED-9B44-04C7954B7328Q30666576-DC978D98-986F-47F7-A440-1374C24B056AQ33279373-6456FABF-D555-4BAB-B192-6D8ECC5F0462Q33474043-3CC548B4-62EE-41DA-9069-300679BF3DD4Q33894681-B0EC4033-D689-49C3-BE07-FF9F06008894Q34066168-BBA7BAE8-6922-4CA4-A095-088DE1158777Q34125201-4E610F23-3E7B-44DD-BEFB-B0096ED3C4D2Q34333161-EE1F566E-5D99-49A9-9A93-129898C93E17Q34429035-30D6E249-2B9C-4024-B4E4-FC37FD9FDA0AQ34489186-A40729F8-CB4C-4B8B-AF8D-00C011D31648Q34515641-18949C75-FE48-4C67-9B70-F2014CB380BAQ34664340-6A11CD3D-C1BE-4FF3-BCCB-C005009F643CQ34742154-865E7C94-AABB-4BD3-A386-52906278D366Q34793213-C8F2E711-8A85-488D-934A-93AB7C2C2C88Q35574809-A039D7E5-0778-409D-AB73-01D724464684Q36018570-95803C7A-B6F1-43E3-A261-1F31D0F8AA4EQ36239537-F2441179-5664-459C-A0D4-9B12667D71D7Q36293675-958FE88F-E971-40C7-8E9E-9BDAB38740D4Q36636989-AA6E50EC-2C7A-42AA-A86C-F48E28487CADQ37217500-B8C25360-0A28-458D-A106-EE55B7FF9EEEQ37727056-5CB3A5F3-57D4-4ACE-85D4-72E7F53D69EAQ37804653-87034021-EE2F-4BF8-BFFD-0CCD696A3519Q37879317-AAFB0D97-F29E-4BF3-BC8C-79A9BBA8EDFDQ37921887-A5D41725-609D-478D-8291-80C6FD073882Q38040267-659EC3C2-1EA3-465B-9C0F-A1CF3AEF757CQ38295152-DBD87B75-6755-4544-BE76-F87268DB815FQ38315864-042A3485-730B-482D-AFAA-5BC07108E51DQ38329036-548D0F2A-912B-4B43-85D1-CC2B75A0D02EQ38534671-F4D67EDE-F3A2-4DFB-AD25-35A2C12A8F60Q39004902-F8523F0D-E153-4C97-8D76-33B10A69EE9F
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Hiroyuki Sorimachi
@ast
Hiroyuki Sorimachi
@en
Hiroyuki Sorimachi
@es
Hiroyuki Sorimachi
@nl
Hiroyuki Sorimachi
@sl
type
label
Hiroyuki Sorimachi
@ast
Hiroyuki Sorimachi
@en
Hiroyuki Sorimachi
@es
Hiroyuki Sorimachi
@nl
Hiroyuki Sorimachi
@sl
prefLabel
Hiroyuki Sorimachi
@ast
Hiroyuki Sorimachi
@en
Hiroyuki Sorimachi
@es
Hiroyuki Sorimachi
@nl
Hiroyuki Sorimachi
@sl
P1053
C-6448-2009
Q-6956-2017
P106
P1153
7006347216
P21
P31
P3829
P496
0000-0001-9509-6727
P569
2000-01-01T00:00:00Z