APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. - Wikidata - thesis-toulmin - TriplyDB

APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.

APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.

http://www.wikidata.org/entity/Q30493956

about

A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6 Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells Hippocampal network oscillations in APP/APLP2-deficient mice Trafficking and proteolytic processing of APP Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity Differential release of β-amyloid from dendrite- versus axon-targeted APP.Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles.Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport.Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production.A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development.LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression.Amyloid precursor protein is trafficked and secreted via synaptic vesicles Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.PAT1 inversely regulates the surface Amyloid Precursor Protein level in mouse primary neurons.Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter.Linking molecular motors to membrane cargo.Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects.Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway.Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking.Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme 1.UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport.Functions of the APP gene family in the nervous system: insights from mouse models.Proteomic analysis of the presynaptic active zone.Physiological functions of APP family proteins.Rab-mediated trafficking role in neurite formation.The synaptic proteome.The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors.FE65 proteins regulate NMDA receptor activation-induced amyloid precursor protein processing.Synaptophysin Is a Reliable Marker for Axonal Damage.Critical importance of RAB proteins for synaptic function.Not just amyloid: physiological functions of the amyloid precursor protein family.Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases.

P2860

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P2860

APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.

http://www.wikidata.org/entity/Q30493956

description

2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

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2009年論文

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2009年论文

@wuu

name

APP anterograde transport requ ...... mbly of the transport vesicle.

@ast

APP anterograde transport requ ...... mbly of the transport vesicle.

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type

label

APP anterograde transport requ ...... mbly of the transport vesicle.

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APP anterograde transport requ ...... mbly of the transport vesicle.

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prefLabel

APP anterograde transport requ ...... mbly of the transport vesicle.

@ast

APP anterograde transport requ ...... mbly of the transport vesicle.

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JNEUROSCI.1546-09.2009

P1433

Journal of Neuroscience

P1476

APP anterograde transport requ ...... mbly of the transport vesicle.

@en

P2093

Anita Szodorai

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Ayuko Sakane

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Gerardo Morfini

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Joachim Kirsch

http://www.w3.org/2001/XMLSchema#string

Scott Brady

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Silke Hunzelmann

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Stefan Kins

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Takuya Sasaki

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Ulrike Engel

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Ulrike Müller

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P2860

The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo

The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors

Molecular cloning and characterization of the noncatalytic subunit of the Rab3 subfamily-specific GTPase-activating protein

Isolation and characterization of a GTPase activating protein specific for the Rab3 subfamily of small G proteins

Real-time imaging of Rab3a and Rab5a reveals differential roles in presynaptic function

Homo- and heterodimerization of APP family members promotes intercellular adhesion.

The amyloid-beta precursor protein: integrating structure with biological function

A standardized kinesin nomenclature

rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles

Alzheimer's disease: genes, proteins, and therapy

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14534-14544

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10.1523/JNEUROSCI.1546-09.2009

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P433

46

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P478

29

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Konrad Beyreuther

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2009-11-01T00:00:00Z

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19923287

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2849269

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