IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation. - Wikidata - thesis-toulmin - TriplyDB

IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.

IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.

http://www.wikidata.org/entity/Q30500880

about

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis Wnt/beta-catenin signaling and small molecule inhibitors Development of anticancer agents targeting the Wnt/β-catenin signaling Microtubules depolymerization caused by the CK1 inhibitor IC261 may be not mediated by CK1 blockage Neurite outgrowth of mature retinal ganglion cells and PC12 cells requires activity of CK1δ and CK1ε Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.Casein kinase 1δ-dependent Wee1 protein degradation.Differential inhibitor sensitivity between human kinases VRK1 and VRK2.CSNK1E/CTNNB1 are synthetic lethal to TP53 in colorectal cancer and are markers for prognosis Drosophila DBT Autophosphorylation of Its C-Terminal Domain Antagonized by SPAG and Involved in UV-Induced Apoptosis Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.Casein kinase 1α has a non-redundant and dominant role within the CK1 family in melanoma progression Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1 Inhibition of αENaC expression and ENaC activity following blockade of the circadian clock-regulatory kinases CK1δ/ε.Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK.Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells.Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2 Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration Therapeutic targeting of casein kinase 1δ in breast cancer Modeling and validating chronic pharmacological manipulation of circadian rhythms Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2.CK1δ: a pharmacologically tractable Achilles' heel of Wnt-driven cancers?Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis.Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties Casein kinases as potential therapeutic targets.A comparative study of hepatitis B virus X protein mutants K130M, V131I and KV130/131MI to investigate their roles in fibrosis, cirrhosis and hepatocellular carcinoma.Mammalian sterile 20-like kinase 1/2 inhibits the Wnt/β-catenin signalling pathway by directly binding casein kinase 1ε.Non-kinase targets of protein kinase inhibitors.Decreased CK1δ expression predicts prolonged survival in colorectal cancer patients.CK1δ in lymphoma: gene expression and mutation analyses and validation of CK1δ kinase activity for therapeutic application.Casein kinase iγ2 impairs fibroblasts actin stress fibers formation and delays cell cycle progression in g1.Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis.Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer.Microtubule Depolymerization by Kinase Inhibitors: Unexpected Findings of Dual Inhibitors.State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261.Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling.CK1ε and p120-catenin control Ror2 function in non-canonical Wnt signaling.Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival

P2860

Q21129297-73B6E0E5-1721-4761-A679-705001CDCD09 Q24597197-E67EB7D3-5FFE-4C89-97DC-95687EBEA072 Q26781898-7C25F202-086C-498B-8FB7-35D94E0D9E8C Q27322976-A4862AE6-7116-4C84-B060-D60F689C9A2B Q28573292-58B04F15-2246-4B93-B380-F1B27E66C281 Q28817964-64EA2F04-C9AA-4B40-9F85-2915FF4F9718 Q33559650-8B5C6F0F-DCD3-4611-85F8-4C7428C60F9B Q33846463-07C33D4A-7373-4D6F-AA59-C30ECFA32CBE Q33988809-645EEA85-01EB-47E6-AB2D-475550A35612 Q34346431-ED5B8DF0-F0FC-49E7-B22A-3DF90CD6216C Q34474923-9184B61A-F4F7-413D-B249-BF3A1FCAC6CA Q35408800-035882A4-F8BA-4308-9FAA-355D9F381C25 Q36094464-54C6A64B-A03A-4EFB-8922-D9462D146036 Q36261341-DBEA7F76-0E2E-48C7-A8CE-E8F23AB296B8 Q36312671-7DB6C0F4-5501-497E-A6F8-837AFDBF5DDD Q36321789-1E13CA61-02AC-45AC-92F9-4CBD6A73DCA6 Q36379515-3E23D1B3-445E-4917-B811-8BC46905C5F3 Q36381686-6D90D051-B9AC-4868-BE87-5F792199836F Q36545282-556960B2-3887-4B2C-95DC-82C815428277 Q36734385-9A740CD7-278F-4059-93BA-6353EEA33EE9 Q37072946-023D0C6C-7E36-454E-9F19-8253D77FF553 Q37164205-0BAF928F-8503-451B-8740-CEEC8C038971 Q37443498-F2649DA8-CB5B-4168-AAA8-579709C8C1CA Q38259229-69B68DE5-65FF-4EF4-9A9A-16289F83DD4A Q38303007-C9574696-9757-47B9-AFD2-04BF5FB647B2 Q38453772-3DF22363-F408-4958-9E72-DF16A4759816 Q38632634-25C2778F-3B80-4172-92E7-FB94E67CA5C9 Q38698878-6CCB5F8C-7961-48A5-98BA-C655E7CCD737 Q39067923-7A6A1098-BF50-43E5-ADAB-5D90397548DE Q39171961-097A2B75-7E45-4C14-BFBC-7A90967C3633 Q40996009-D1437C10-A495-4279-946F-11EC9EF00FF3 Q42204673-F64FB110-AE7A-4854-BF86-BAC0F3C6A172 Q42566933-03D2770B-36D0-42CF-8DF6-BECBA2AA6AB5 Q47748570-195747CA-8A1C-428E-9C24-07E539F9D218 Q47889349-CEE9C411-FCD0-44D1-BAE0-47C941103929 Q48246859-2177995D-7081-4034-A1FD-18402CA632B7 Q48274837-EA4BF580-C6BD-47DF-B06F-0F01FEB8CB7A Q48332986-2C65B61D-5AB2-4917-A897-E53ACAC33B96 Q49710345-DF52B24F-4495-4435-8E0C-B9C94C68B88A Q58751776-24270042-6067-4FA5-B288-DFE5D60C2788

P2860

IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.

http://www.wikidata.org/entity/Q30500880

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

IC261 induces cell cycle arres ...... of mitotic spindle formation.

@ast

IC261 induces cell cycle arres ...... of mitotic spindle formation.

@en

type

label

IC261 induces cell cycle arres ...... of mitotic spindle formation.

@ast

IC261 induces cell cycle arres ...... of mitotic spindle formation.

@en

prefLabel

IC261 induces cell cycle arres ...... of mitotic spindle formation.

@ast

IC261 induces cell cycle arres ...... of mitotic spindle formation.

@en

P1433

Q30500880-214BAD7C-A3DD-4344-895C-0AAC5B15BFD6

P1476

Q30500880-57A0E0CB-F698-40D3-8E57-DC92E867B3BE

P2093

Q30500880-21B53B55-69C1-4DC2-9EB3-D2925FA4F713

Q30500880-50A41BDD-C049-4A3F-8CFA-2EA0EFFEE771

Q30500880-74A0DF40-FDD6-4FE6-B1E8-834B7877123E

Q30500880-AB6B0DF8-FDB2-4E0A-ACA5-9EE70388310B

Q30500880-F06239B4-45D4-477E-854C-2D98820BDE43

P2860

Q30500880-00B8C169-6E22-431D-A553-81B33D62A9FE

Q30500880-06A80227-EB10-4F66-8FAA-CFCC42D91BF3

Q30500880-09DEBE3C-14B7-4652-BBB6-176AF92A9758

Q30500880-1C2769C2-0BF4-4AFF-905C-BB70680A6BB0

Q30500880-1F319485-C62A-4325-A041-73FE19A39A6F

Q30500880-235A6E55-B7D7-47E1-9A6E-EA2357CFA410

Q30500880-25029BB7-5C34-45F8-90F4-4D4F543F1786

Q30500880-26746C89-EF79-43F4-BA7E-F2167561FA78

Q30500880-28BC0D94-7E46-4785-BB4A-2C9E5FA13457

Q30500880-2965A639-212D-4CDF-980F-38C68DB651C3

P2888

Q30500880-85E428B5-0FA0-4C5F-976C-2FE2821B7A28

P304

Q30500880-A2E3EE41-8AE5-422D-8102-94C88A3DE880

P31

Q30500880-EB02A09C-7895-40A6-A194-9C4A57C292DB

P356

Q30500880-C7CC2601-9502-493D-BF17-9A523F8B7FE5

P407

Q30500880-9E801886-42FD-4A93-9828-AEA335EAAEBD

P433

Q30500880-253947EB-D109-4C24-8EF8-EC418FEB4BAB

P478

Q30500880-45CAF31C-1DE5-4AB2-BF57-5DB74C5D5DB2

P50

Q30500880-61B8C98A-FD66-4D86-A9EB-43B851D8D208

Q30500880-FDDEC5DE-CDBF-40EF-A556-98E2166AF376

P577

Q30500880-1384EE9A-58A1-406B-9964-0D3A4D5C8E78

P5875

Q30500880-622C9B69-12B7-44CF-99E2-74E7B1B1448F

P6179

Q30500880-2394C84A-39F7-4109-9754-D7F112B3BCE8

P698

Q30500880-1DFEEB6C-F98D-4530-A91D-9913035C1CB0

P921

Q30500880-3F1CBE75-1D5C-4546-BCFF-C6CBC37F3C67

P932

Q30500880-5E8CFA62-32F9-42D6-B0CE-8D74671586F9

P356

P1433

P1476

IC261 induces cell cycle arres ...... n of mitotic spindle formation

@en

P2093

J K Cheong

http://www.w3.org/2001/XMLSchema#string

P M Voorhoeve

http://www.w3.org/2001/XMLSchema#string

P Tan

http://www.w3.org/2001/XMLSchema#string

S H Lee

http://www.w3.org/2001/XMLSchema#string

T H Nguyen

http://www.w3.org/2001/XMLSchema#string

P2860

Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon

Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells

The interaction between casein kinase Ialpha and 14-3-3 is phosphorylation dependent

Identification of a new family of protein phosphatase 2A regulatory subunits

Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex

Significance analysis of microarrays applied to the ionizing radiation response

Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins

Cluster analysis and display of genome-wide expression patterns

DOUBLETIME plays a noncatalytic role to mediate CLOCK phosphorylation and repress CLOCK-dependent transcription within the Drosophila circadian clock

Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function

P2888

P304

2558-2569

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/ONC.2010.627

http://www.w3.org/2001/XMLSchema#string

P407

P433

22

http://www.w3.org/2001/XMLSchema#string

P478

30

http://www.w3.org/2001/XMLSchema#string

P50

David M. Virshup

P577

2011-01-24T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

49777612

http://www.w3.org/2001/XMLSchema#string

P6179

1017785423

http://www.w3.org/2001/XMLSchema#string

P698

21258417

http://www.w3.org/2001/XMLSchema#string

P921

P932

3109269

http://www.w3.org/2001/XMLSchema#string