about
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complexThe B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasmIdentification of a new family of protein phosphatase 2A regulatory subunitsCasein kinase I phosphorylates and destabilizes the beta-catenin degradation complexNuclear export of mammalian PERIOD proteinsThe circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase IepsilonSetting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteinsAltered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalitiesPhosphopeptide mapping of proteins ectopically expressed in tissue culture cell linesWLS retrograde transport to the endoplasmic reticulum during Wnt secretionCasein kinase I: another cog in the circadian clockworksRegulation of casein kinase I epsilon activity by Wnt signalingReversible protein phosphorylation regulates circadian rhythmsWnt inhibition enhances browning of mouse primary white adipocytesWLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidificationIC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivativesCarteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp.A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities.Molecular Mechanisms Regulating Temperature Compensation of the Circadian Clock.Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation.Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer.Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during agingProtein phosphatase 2A: a panoply of enzymes.FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway.Disulfide bond requirements for active Wnt ligands.Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A.PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferationUpdating the Wnt pathways.Post-translational modifications regulate the ticking of the circadian clock.Beyond intuitive modeling: combining biophysical models with innovative experiments to move the circadian clock field forward.An opposite role for tau in circadian rhythms revealed by mathematical modelingCasein kinase I in the mammalian circadian clockMoving upstream in the war on WNTs.Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer.TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome.The nucleophosmin-anaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas.Protein serine/threonine phosphatases: life, death, and sleeping.Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
David M Virshup
@nl
David M Virshup
@sl
David M. Virshup
@en
David M. Virshup
@es
type
label
David M Virshup
@nl
David M Virshup
@sl
David M. Virshup
@en
David M. Virshup
@es
altLabel
David Virshup
@en
prefLabel
David M Virshup
@nl
David M Virshup
@sl
David M. Virshup
@en
David M. Virshup
@es
P108
P106
P1153
7006167695
P21
P31
P496
0000-0001-6976-850X