Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease.
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The role of lipoxygenases in pathophysiology; new insights and future perspectivesThe 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer's disease phenotypeZileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease miceAbsence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles.Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tanglesRegulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidencePharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy.Modulation of lipopolysaccharide-induced memory insult, γ-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase.Homocysteine modulates 5-lipoxygenase expression level via DNA methylation.Novel lipid signaling pathways in Alzheimer's disease pathogenesis.Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.The Lipoxygenases: Their Regulation and Implication in Alzheimer's Disease.The 5-Lipoxygenase as modulator of Alzheimer's γ-secretase and therapeutic target.Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, Aβ and tau neuropathology in the triple-transgenic mice.Dissecting the Role of 5-Lipoxygenase in the Homocysteine-Induced Alzheimer's Disease Pathology.The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy.Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy.Brain 5-lipoxygenase over-expression worsens memory, synaptic integrity, and tau pathology in the P301S mice.Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology.Caspase-3-dependent cleavage of Akt modulates tau phosphorylation via GSK3β kinase: implications for Alzheimer's disease.Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice.Novel Key Players in the Development of Tau Neuropathology: Focus on the 5-Lipoxygenase.
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P2860
Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease.
description
2013 nî lūn-bûn
@nan
2013 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մարտին հրատարակված գիտական հոդված
@hy
2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Gene knockout of 5-lipoxygenas ...... model of Alzheimer's disease.
@ast
Gene knockout of 5-lipoxygenas ...... model of Alzheimer's disease.
@en
type
label
Gene knockout of 5-lipoxygenas ...... model of Alzheimer's disease.
@ast
Gene knockout of 5-lipoxygenas ...... model of Alzheimer's disease.
@en
prefLabel
Gene knockout of 5-lipoxygenas ...... model of Alzheimer's disease.
@ast
Gene knockout of 5-lipoxygenas ...... model of Alzheimer's disease.
@en
P2093
P2860
P356
P1433
P1476
Gene knockout of 5-lipoxygenas ...... model of Alzheimer's disease.
@en
P2093
P F Giannopoulos
P2860
P2888
P304
P356
10.1038/MP.2013.23
P407
P577
2013-03-12T00:00:00Z