Reconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin.
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Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating PositionQuantitative detection of 8-Oxo-7,8-dihydro-2'-deoxyguanosine using chemical tagging and qPCRSingle-molecule analysis of thymine dimer-containing G-quadruplexes formed from the human telomere sequence.Spirodi(iminohydantoin) products from oxidation of 2'-deoxyguanosine in the presence of NH4Cl in nucleoside and oligodeoxynucleotide contexts.The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures5-Carboxamido-5-formamido-2-iminohydantoin, in Addition to 8-oxo-7,8-Dihydroguanine, Is the Major Product of the Iron-Fenton or X-ray Radiation-Induced Oxidation of Guanine under Aerobic Reducing Conditions in Nucleoside and DNA ContextsBase and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA.pH-Dependent Equilibrium between 5-Guanidinohydantoin and Iminoallantoin Affects Nucleotide Insertion Opposite the DNA Lesion.Effect of Base-Pairing Partner on the Thermodynamic Stability of the Diastereomeric Spiroiminodihydantoin Lesion.Guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair.Klenow Fragment Discriminates against the Incorporation of the Hyperoxidized dGTP Lesion Spiroiminodihydantoin into DNA.Reverse Transcription Past Products of Guanine Oxidation in RNA Leads to Insertion of A and C opposite 8-Oxo-7,8-dihydroguanine and A and G opposite 5-Guanidinohydantoin and Spiroiminodihydantoin Diastereomers.The Nonbulky DNA Lesions Spiroiminodihydantoin and 5-Guanidinohydantoin Significantly Block Human RNA Polymerase II Elongation in Vitro.Good Computational Practice in the Assignment of Absolute Configurations by TDDFT Calculations of ECD Spectra.Removal of oxidatively generated DNA damage by overlapping repair pathways.Formation and processing of DNA damage substrates for the hNEIL enzymes.Rates of chemical cleavage of DNA and RNA oligomers containing guanine oxidation products.Formation and repair of oxidatively generated damage in cellular DNA.Analysis of guanine oxidation products in double-stranded DNA and proposed guanine oxidation pathways in single-stranded, double-stranded or quadruplex DNA.The R- and S-diastereoisomeric effects on the guanidinohydantoin-induced mutations in DNA.Computational studies of electronic circular dichroism spectra predict absolute configuration assignments for the guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin.8-Oxo-7,8-dihydro-2'-deoxyguanosine and abasic site tandem lesions are oxidation prone yielding hydantoin products that strongly destabilize duplex DNA.Interrogation of Base Pairing of the Spiroiminodihydantoin Diastereomers Using the α-Hemolysin Latch.The shape of the electronic circular dichroism spectrum of (2,6-dimethylphenyl)(phenyl)methanol: interplay between conformational equilibria and vibronic effects.The assignment of the configuration for α-hydroxy acid esters using a CEC strategy.
P2860
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P2860
Reconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin.
description
2013 nî lūn-bûn
@nan
2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Reconciliation of chemical, en ...... lesion spiroiminodihydantoin.
@ast
Reconciliation of chemical, en ...... lesion spiroiminodihydantoin.
@en
type
label
Reconciliation of chemical, en ...... lesion spiroiminodihydantoin.
@ast
Reconciliation of chemical, en ...... lesion spiroiminodihydantoin.
@en
prefLabel
Reconciliation of chemical, en ...... lesion spiroiminodihydantoin.
@ast
Reconciliation of chemical, en ...... lesion spiroiminodihydantoin.
@en
P2093
P2860
P356
P1476
Reconciliation of chemical, en ...... lesion spiroiminodihydantoin.
@en
P2093
Aaron M Fleming
Anita M Orendt
Cynthia J Burrows
Rina K Dukor
P2860
P304
18191-18204
P356
10.1021/JA409254Z
P407
P577
2013-11-21T00:00:00Z