Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position
about
Spirodi(iminohydantoin) products from oxidation of 2'-deoxyguanosine in the presence of NH4Cl in nucleoside and oligodeoxynucleotide contexts.Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide5-Carboxamido-5-formamido-2-iminohydantoin, in Addition to 8-oxo-7,8-Dihydroguanine, Is the Major Product of the Iron-Fenton or X-ray Radiation-Induced Oxidation of Guanine under Aerobic Reducing Conditions in Nucleoside and DNA ContextsBase and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA.Effect of Base-Pairing Partner on the Thermodynamic Stability of the Diastereomeric Spiroiminodihydantoin Lesion.Klenow Fragment Discriminates against the Incorporation of the Hyperoxidized dGTP Lesion Spiroiminodihydantoin into DNA.Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable LiabilityRemoval of oxidatively generated DNA damage by overlapping repair pathways.Rates of chemical cleavage of DNA and RNA oligomers containing guanine oxidation products.The R- and S-diastereoisomeric effects on the guanidinohydantoin-induced mutations in DNA.Computational studies of electronic circular dichroism spectra predict absolute configuration assignments for the guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin.8-Oxo-7,8-dihydro-2'-deoxyguanosine and abasic site tandem lesions are oxidation prone yielding hydantoin products that strongly destabilize duplex DNA.The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation.Conformational stabilities of iminoallantoin and its base pairs in DNA: implications for mutagenicity.
P2860
Q34992472-9D1A22D1-B522-4490-B5EE-168A0B14108AQ35032502-1421F07F-D310-4A7B-B248-D74B7F04BDDBQ35871453-0CE17548-0265-4EF8-8621-57A0ABC4E74DQ35886189-95087F90-4B4F-477D-B36B-B734E35FF4A6Q36723229-D18043B3-EBCC-4CA5-B8EF-5460CAB232E7Q36883547-76DB529A-5EE0-4E62-9C94-0C38B67B0784Q38943129-6967481A-7237-4CCB-94FF-37A8E9A3335FQ39000410-B760D527-8A5C-42AC-BB90-D966EB36DBE0Q39020441-FEB979DB-9E6B-4C47-8A88-AA6838A4DC3AQ40811126-DB5F2789-170D-4742-94D7-8C2417371257Q42424517-E0E31735-ADC2-4D40-AA23-4C7EFF9AA801Q46303021-0ACA5B85-2390-4194-9D16-1F0B9CC5F57EQ47100233-1ADA54DA-E839-481B-A983-AB7FEC060741Q54163647-BE31C9DD-A426-4A2A-86B7-40128C7CDE6F
P2860
Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position
description
2014 nî lūn-bûn
@nan
2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Crystal Structure of DNA Polym ...... ntoin in a Templating Position
@ast
Crystal Structure of DNA Polym ...... ntoin in a Templating Position
@en
Crystal Structure of DNA Polym ...... ntoin in a Templating Position
@nl
type
label
Crystal Structure of DNA Polym ...... ntoin in a Templating Position
@ast
Crystal Structure of DNA Polym ...... ntoin in a Templating Position
@en
Crystal Structure of DNA Polym ...... ntoin in a Templating Position
@nl
prefLabel
Crystal Structure of DNA Polym ...... ntoin in a Templating Position
@ast
Crystal Structure of DNA Polym ...... ntoin in a Templating Position
@en
Crystal Structure of DNA Polym ...... ntoin in a Templating Position
@nl
P2093
P2860
P356
P1433
P1476
Crystal Structure of DNA Polym ...... ntoin in a Templating Position
@en
P2093
Aaron M Fleming
Brian E Eckenroth
Cynthia J Burrows
Joann B Sweasy
P2860
P304
P356
10.1021/BI500270E
P407
P577
2014-04-08T00:00:00Z